Investigations of the Kinetics and Mechanism of Reduction of a Carboplatin Pt(IV) Prodrug by the Major Small-Molecule Reductants in Human Plasma

The development of Pt(IV) anticancer prodrugs to overcome the detrimental side effects of Pt(II)-based anticancer drugs is of current interest. The kinetics and reaction mechanisms of the reductive activation of the carboplatin Pt(IV) prodrug cis,trans-[Pt(cbdca)(NH(3))(2)Cl(2)] (cbdca = cyclobutane...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Tian, Hongwu, Xu, Liyao, Zhou, Li, Wang, Jinhu, Xu, Benyan, Liu, Chunli, Elding, Lars I., Shi, Tiesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888404/
https://www.ncbi.nlm.nih.gov/pubmed/31726728
http://dx.doi.org/10.3390/ijms20225660

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