An Overview of Drug Resistance in Protozoal Diseases

Protozoan diseases continue to be a worldwide social and economic health problem. Increased drug resistance, emerging cross resistance, and lack of new drugs with novel mechanisms of action significantly reduce the effectiveness of current antiprotozoal therapies. While drug resistance associated to...

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Detalles Bibliográficos
Autores principales: Capela, Rita, Moreira, Rui, Lopes, Francisca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888673/
https://www.ncbi.nlm.nih.gov/pubmed/31731801
http://dx.doi.org/10.3390/ijms20225748
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author Capela, Rita
Moreira, Rui
Lopes, Francisca
author_facet Capela, Rita
Moreira, Rui
Lopes, Francisca
author_sort Capela, Rita
collection PubMed
description Protozoan diseases continue to be a worldwide social and economic health problem. Increased drug resistance, emerging cross resistance, and lack of new drugs with novel mechanisms of action significantly reduce the effectiveness of current antiprotozoal therapies. While drug resistance associated to anti-infective agents is a reality, society seems to remain unaware of its proportions and consequences. Parasites usually develops ingenious and innovative mechanisms to achieve drug resistance, which requires more research and investment to fight it. In this review, drug resistance developed by protozoan parasites Plasmodium, Leishmania, and Trypanosoma will be discussed.
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spelling pubmed-68886732019-12-09 An Overview of Drug Resistance in Protozoal Diseases Capela, Rita Moreira, Rui Lopes, Francisca Int J Mol Sci Review Protozoan diseases continue to be a worldwide social and economic health problem. Increased drug resistance, emerging cross resistance, and lack of new drugs with novel mechanisms of action significantly reduce the effectiveness of current antiprotozoal therapies. While drug resistance associated to anti-infective agents is a reality, society seems to remain unaware of its proportions and consequences. Parasites usually develops ingenious and innovative mechanisms to achieve drug resistance, which requires more research and investment to fight it. In this review, drug resistance developed by protozoan parasites Plasmodium, Leishmania, and Trypanosoma will be discussed. MDPI 2019-11-15 /pmc/articles/PMC6888673/ /pubmed/31731801 http://dx.doi.org/10.3390/ijms20225748 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Capela, Rita
Moreira, Rui
Lopes, Francisca
An Overview of Drug Resistance in Protozoal Diseases
title An Overview of Drug Resistance in Protozoal Diseases
title_full An Overview of Drug Resistance in Protozoal Diseases
title_fullStr An Overview of Drug Resistance in Protozoal Diseases
title_full_unstemmed An Overview of Drug Resistance in Protozoal Diseases
title_short An Overview of Drug Resistance in Protozoal Diseases
title_sort overview of drug resistance in protozoal diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888673/
https://www.ncbi.nlm.nih.gov/pubmed/31731801
http://dx.doi.org/10.3390/ijms20225748
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