Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer

Sirtuins, a family of nicotinamide adenine dinucleotide (NAD(+))-dependent lysine deacetylases, are promising targets for anticancer treatment. Recently, we characterized a novel pan-sirtuin (SIRT) inhibitor, MC2494, displaying antiproliferative effects and able to induce death pathways in several h...

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Detalles Bibliográficos
Autores principales: Carafa, Vincenzo, Poziello, Angelita, Della Torre, Laura, Giovannelli, Pia, Di Donato, Marzia, Safadeh, Elham, Yu, Zhijun, Baldi, Alfonso, Castoria, Gabriella, Tomaselli, Daniela, Mai, Antonello, Rotili, Dante, Nebbioso, Angela, Altucci, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888689/
https://www.ncbi.nlm.nih.gov/pubmed/31726691
http://dx.doi.org/10.3390/ijms20225654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888689/
https://www.ncbi.nlm.nih.gov/pubmed/31726691
http://dx.doi.org/10.3390/ijms20225654

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