KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization

Epigenomic changes and stem cell deterioration are two hallmarks of aging. Accumulating evidence suggest that senescence of mesenchymal stromal cells (MSCs) perpetuates aging or age-related diseases. Here we report that two H3K9 demethylases, KDM3A and KDM4C, regulate heterochromatin reorganization...

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Detalles Bibliográficos
Autores principales: Huang, Biao, Wang, Bin, Yuk-Wai Lee, Wayne, Pong U, Kin, Leung, Kam Tong, Li, Xican, Liu, Zhenqing, Chen, Rui, Lin, Jia cheng, Tsang, Lai Ling, Liu, Baohua, Ruan, Ye chun, Chan, Hsiao Chang, Li, Gang, Jiang, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888768/
https://www.ncbi.nlm.nih.gov/pubmed/31704649
http://dx.doi.org/10.1016/j.isci.2019.10.041

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