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Protective effects of Salidroside on cardiac function in mice with myocardial infarction
Salidroside (SAL) is the major ingredient of Rhodiola rosea, and has been traditionally used in Chinese medicine for decades. Numerous studies have demonstrated the protective effects of SAL for myocardial ischemia. However, it is yet to be deciphered whether SAL has cardioprotective effects after m...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888872/ https://www.ncbi.nlm.nih.gov/pubmed/31792327 http://dx.doi.org/10.1038/s41598-019-54713-x |
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author | Chen, Pengsheng Liu, Jia Ruan, Hongyun Zhang, Miaomiao Wu, Peng Yimei, Du Han, Bing |
author_facet | Chen, Pengsheng Liu, Jia Ruan, Hongyun Zhang, Miaomiao Wu, Peng Yimei, Du Han, Bing |
author_sort | Chen, Pengsheng |
collection | PubMed |
description | Salidroside (SAL) is the major ingredient of Rhodiola rosea, and has been traditionally used in Chinese medicine for decades. Numerous studies have demonstrated the protective effects of SAL for myocardial ischemia. However, it is yet to be deciphered whether SAL has cardioprotective effects after myocardial infarction (MI) in vivo. In the present study, we established a mouse MI model via coronary artery ligation. The aim was to investigate whether SAL treatment could reduce mortality, improve cardiac function and attenuate myocardial remodeling in MI mice. Post-surgery, mice were randomly administered SAL or normal saline. After 21 days, SAL was found to significantly reduce mortality, improve cardiac function, reduce fibrosis and infarct size compared to normal saline. In addition, oral administration of SAL could attenuate myocardial inflammation and apoptosis and promote angiogenesis. SAL down-regulated the expression levels of TNF-α, TGF-β1, IL-1β, Bax and up-regulate the expression of Bcl-2, VEGF, Akt and eNOS. These results indicated that SAL could alleviate the pathological processes of myocardial remodeling in MI mice, and may be a potentially effective therapeutic approach for the management of clinical ischemic cardiovascular diseases. |
format | Online Article Text |
id | pubmed-6888872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68888722019-12-10 Protective effects of Salidroside on cardiac function in mice with myocardial infarction Chen, Pengsheng Liu, Jia Ruan, Hongyun Zhang, Miaomiao Wu, Peng Yimei, Du Han, Bing Sci Rep Article Salidroside (SAL) is the major ingredient of Rhodiola rosea, and has been traditionally used in Chinese medicine for decades. Numerous studies have demonstrated the protective effects of SAL for myocardial ischemia. However, it is yet to be deciphered whether SAL has cardioprotective effects after myocardial infarction (MI) in vivo. In the present study, we established a mouse MI model via coronary artery ligation. The aim was to investigate whether SAL treatment could reduce mortality, improve cardiac function and attenuate myocardial remodeling in MI mice. Post-surgery, mice were randomly administered SAL or normal saline. After 21 days, SAL was found to significantly reduce mortality, improve cardiac function, reduce fibrosis and infarct size compared to normal saline. In addition, oral administration of SAL could attenuate myocardial inflammation and apoptosis and promote angiogenesis. SAL down-regulated the expression levels of TNF-α, TGF-β1, IL-1β, Bax and up-regulate the expression of Bcl-2, VEGF, Akt and eNOS. These results indicated that SAL could alleviate the pathological processes of myocardial remodeling in MI mice, and may be a potentially effective therapeutic approach for the management of clinical ischemic cardiovascular diseases. Nature Publishing Group UK 2019-12-02 /pmc/articles/PMC6888872/ /pubmed/31792327 http://dx.doi.org/10.1038/s41598-019-54713-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chen, Pengsheng Liu, Jia Ruan, Hongyun Zhang, Miaomiao Wu, Peng Yimei, Du Han, Bing Protective effects of Salidroside on cardiac function in mice with myocardial infarction |
title | Protective effects of Salidroside on cardiac function in mice with myocardial infarction |
title_full | Protective effects of Salidroside on cardiac function in mice with myocardial infarction |
title_fullStr | Protective effects of Salidroside on cardiac function in mice with myocardial infarction |
title_full_unstemmed | Protective effects of Salidroside on cardiac function in mice with myocardial infarction |
title_short | Protective effects of Salidroside on cardiac function in mice with myocardial infarction |
title_sort | protective effects of salidroside on cardiac function in mice with myocardial infarction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888872/ https://www.ncbi.nlm.nih.gov/pubmed/31792327 http://dx.doi.org/10.1038/s41598-019-54713-x |
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