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Gene activation by dCas9-CBP and the SAM system differ in target preference
Gene overexpression through the targeting of transcription activation domains to regulatory DNA via catalytically defective Cas9 (dCas9) represents a powerful approach to investigate gene function as well as the mechanisms of gene control. To date, the most efficient dCas9-based activator is the Syn...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888908/ https://www.ncbi.nlm.nih.gov/pubmed/31792240 http://dx.doi.org/10.1038/s41598-019-54179-x |