Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts

BACKGROUND: The limited proliferative ability of hepatocytes is a major limitation to meet their demand for cell-based therapy, bio-artificial liver device, and drug tests. One strategy is to amplify cells at the hepatoblast (HB) stage. However, expansion of HBs with their bipotency preserved is cha...

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Detalles Bibliográficos
Autores principales: Pan, Tingcai, Chen, Yan, Zhuang, Yuanqi, Yang, Fan, Xu, Yingying, Tao, Jiawang, You, Kai, Wang, Ning, Wu, Yuhang, Lin, Xianhua, Wu, Feima, Liu, Yanli, Li, Yingrui, Wang, Guodong, Li, Yin-xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888929/
https://www.ncbi.nlm.nih.gov/pubmed/31791391
http://dx.doi.org/10.1186/s13287-019-1463-y

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