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Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs

Finding effective predictors of traits related to boar fertility is essential for increasing the efficiency of artificial insemination systems in pig breeding. The objective of this study was to find associations between single-nucleotide polymorphisms (SNPs) within candidate genes and fertility in...

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Autores principales: Tremoen, Nina Hårdnes, Van Son, Maren, Andersen-Ranberg, Ina, Grindflek, Eli, Myromslien, Frøydis Deinboll, Gaustad, Ann Helen, Våge, Dag Inge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888942/
https://www.ncbi.nlm.nih.gov/pubmed/31796051
http://dx.doi.org/10.1186/s13028-019-0493-x
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author Tremoen, Nina Hårdnes
Van Son, Maren
Andersen-Ranberg, Ina
Grindflek, Eli
Myromslien, Frøydis Deinboll
Gaustad, Ann Helen
Våge, Dag Inge
author_facet Tremoen, Nina Hårdnes
Van Son, Maren
Andersen-Ranberg, Ina
Grindflek, Eli
Myromslien, Frøydis Deinboll
Gaustad, Ann Helen
Våge, Dag Inge
author_sort Tremoen, Nina Hårdnes
collection PubMed
description Finding effective predictors of traits related to boar fertility is essential for increasing the efficiency of artificial insemination systems in pig breeding. The objective of this study was to find associations between single-nucleotide polymorphisms (SNPs) within candidate genes and fertility in the breeds Landrace and Duroc. Animals with breeding values for total number of piglets born, were re-sequenced for exonic regions of 14 candidate genes related to male and female fertility using samples from 16 Landrace boars and 16 Duroc boars (four with high and four with low breeding value of total number of piglets born for each breed for male fertility, and the same for female fertility) to detect genetic variants. Genotyping for the detected SNPs was done in 619 Landrace boars and 513 Duroc boars. Two SNPs in BMPR1 and one SNP in COX-2 were found significantly associated with the total number of piglets born in Landrace. In Duroc, two SNPs in PLC(z), one SNP in VWF and one SNP in ZP3 were found significantly associated with total number of piglets born. These SNPs explained between 0.27% and 1.18% of the genetic variance. These effects are too low for being used directly for selection purposes but can be of interest in SNP-panels used for genomic selection.
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spelling pubmed-68889422019-12-11 Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs Tremoen, Nina Hårdnes Van Son, Maren Andersen-Ranberg, Ina Grindflek, Eli Myromslien, Frøydis Deinboll Gaustad, Ann Helen Våge, Dag Inge Acta Vet Scand Brief Communication Finding effective predictors of traits related to boar fertility is essential for increasing the efficiency of artificial insemination systems in pig breeding. The objective of this study was to find associations between single-nucleotide polymorphisms (SNPs) within candidate genes and fertility in the breeds Landrace and Duroc. Animals with breeding values for total number of piglets born, were re-sequenced for exonic regions of 14 candidate genes related to male and female fertility using samples from 16 Landrace boars and 16 Duroc boars (four with high and four with low breeding value of total number of piglets born for each breed for male fertility, and the same for female fertility) to detect genetic variants. Genotyping for the detected SNPs was done in 619 Landrace boars and 513 Duroc boars. Two SNPs in BMPR1 and one SNP in COX-2 were found significantly associated with the total number of piglets born in Landrace. In Duroc, two SNPs in PLC(z), one SNP in VWF and one SNP in ZP3 were found significantly associated with total number of piglets born. These SNPs explained between 0.27% and 1.18% of the genetic variance. These effects are too low for being used directly for selection purposes but can be of interest in SNP-panels used for genomic selection. BioMed Central 2019-12-03 /pmc/articles/PMC6888942/ /pubmed/31796051 http://dx.doi.org/10.1186/s13028-019-0493-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Brief Communication
Tremoen, Nina Hårdnes
Van Son, Maren
Andersen-Ranberg, Ina
Grindflek, Eli
Myromslien, Frøydis Deinboll
Gaustad, Ann Helen
Våge, Dag Inge
Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs
title Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs
title_full Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs
title_fullStr Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs
title_full_unstemmed Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs
title_short Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs
title_sort association between single-nucleotide polymorphisms within candidate genes and fertility in landrace and duroc pigs
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888942/
https://www.ncbi.nlm.nih.gov/pubmed/31796051
http://dx.doi.org/10.1186/s13028-019-0493-x
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