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Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs
Finding effective predictors of traits related to boar fertility is essential for increasing the efficiency of artificial insemination systems in pig breeding. The objective of this study was to find associations between single-nucleotide polymorphisms (SNPs) within candidate genes and fertility in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888942/ https://www.ncbi.nlm.nih.gov/pubmed/31796051 http://dx.doi.org/10.1186/s13028-019-0493-x |
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author | Tremoen, Nina Hårdnes Van Son, Maren Andersen-Ranberg, Ina Grindflek, Eli Myromslien, Frøydis Deinboll Gaustad, Ann Helen Våge, Dag Inge |
author_facet | Tremoen, Nina Hårdnes Van Son, Maren Andersen-Ranberg, Ina Grindflek, Eli Myromslien, Frøydis Deinboll Gaustad, Ann Helen Våge, Dag Inge |
author_sort | Tremoen, Nina Hårdnes |
collection | PubMed |
description | Finding effective predictors of traits related to boar fertility is essential for increasing the efficiency of artificial insemination systems in pig breeding. The objective of this study was to find associations between single-nucleotide polymorphisms (SNPs) within candidate genes and fertility in the breeds Landrace and Duroc. Animals with breeding values for total number of piglets born, were re-sequenced for exonic regions of 14 candidate genes related to male and female fertility using samples from 16 Landrace boars and 16 Duroc boars (four with high and four with low breeding value of total number of piglets born for each breed for male fertility, and the same for female fertility) to detect genetic variants. Genotyping for the detected SNPs was done in 619 Landrace boars and 513 Duroc boars. Two SNPs in BMPR1 and one SNP in COX-2 were found significantly associated with the total number of piglets born in Landrace. In Duroc, two SNPs in PLC(z), one SNP in VWF and one SNP in ZP3 were found significantly associated with total number of piglets born. These SNPs explained between 0.27% and 1.18% of the genetic variance. These effects are too low for being used directly for selection purposes but can be of interest in SNP-panels used for genomic selection. |
format | Online Article Text |
id | pubmed-6888942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68889422019-12-11 Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs Tremoen, Nina Hårdnes Van Son, Maren Andersen-Ranberg, Ina Grindflek, Eli Myromslien, Frøydis Deinboll Gaustad, Ann Helen Våge, Dag Inge Acta Vet Scand Brief Communication Finding effective predictors of traits related to boar fertility is essential for increasing the efficiency of artificial insemination systems in pig breeding. The objective of this study was to find associations between single-nucleotide polymorphisms (SNPs) within candidate genes and fertility in the breeds Landrace and Duroc. Animals with breeding values for total number of piglets born, were re-sequenced for exonic regions of 14 candidate genes related to male and female fertility using samples from 16 Landrace boars and 16 Duroc boars (four with high and four with low breeding value of total number of piglets born for each breed for male fertility, and the same for female fertility) to detect genetic variants. Genotyping for the detected SNPs was done in 619 Landrace boars and 513 Duroc boars. Two SNPs in BMPR1 and one SNP in COX-2 were found significantly associated with the total number of piglets born in Landrace. In Duroc, two SNPs in PLC(z), one SNP in VWF and one SNP in ZP3 were found significantly associated with total number of piglets born. These SNPs explained between 0.27% and 1.18% of the genetic variance. These effects are too low for being used directly for selection purposes but can be of interest in SNP-panels used for genomic selection. BioMed Central 2019-12-03 /pmc/articles/PMC6888942/ /pubmed/31796051 http://dx.doi.org/10.1186/s13028-019-0493-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Brief Communication Tremoen, Nina Hårdnes Van Son, Maren Andersen-Ranberg, Ina Grindflek, Eli Myromslien, Frøydis Deinboll Gaustad, Ann Helen Våge, Dag Inge Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs |
title | Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs |
title_full | Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs |
title_fullStr | Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs |
title_full_unstemmed | Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs |
title_short | Association between single-nucleotide polymorphisms within candidate genes and fertility in Landrace and Duroc pigs |
title_sort | association between single-nucleotide polymorphisms within candidate genes and fertility in landrace and duroc pigs |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888942/ https://www.ncbi.nlm.nih.gov/pubmed/31796051 http://dx.doi.org/10.1186/s13028-019-0493-x |
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