Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis

Prostate cancer (PCa) metastasizes selectively to bone through unknown mechanisms. In the current study, we identified exosome-mediated transfer of pyruvate kinase M2 (PKM2) from PCa cells into bone marrow stromal cells (BMSCs) as a novel mechanism through which primary tumor-derived exosomes promot...

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Detalles Bibliográficos
Autores principales: Dai, Jinlu, Escara-Wilke, June, Keller, Jill M., Jung, Younghun, Taichman, Russell S., Pienta, Kenneth J., Keller, Evan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888980/
https://www.ncbi.nlm.nih.gov/pubmed/31548301
http://dx.doi.org/10.1084/jem.20190158

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