Grb2 dimer interacts with Coumarin through SH2 domains: A combined experimental and molecular modeling study

Grb2 is an important regulator of normal vs. oncogenic cell signaling transduction. It plays a pivotal role on kinase-mediated signaling transduction by linking Receptor Tyrosine kinases to Ras/MAPK pathway which is known to bring oncogenic outcome. Coumarins are phenolic molecules found in several...

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Detalles Bibliográficos
Autores principales: Sanches, Karoline, Dias, Raphael Vinicius Rodrigues, da Silva, Paulo Henrique, Fossey, Marcelo Andrés, Caruso, Ícaro Putinhon, de Souza, Fátima Pereira, de Oliveira, Leandro Cristante, de Melo, Fernando Alves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889026/
https://www.ncbi.nlm.nih.gov/pubmed/31844748
http://dx.doi.org/10.1016/j.heliyon.2019.e02869

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