Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones

The divergent reactivity of 5-allenyloxazolidinones has been explored. This novel building block undergoes Pd(0)-catalyzed cross-coupling with boronic acids to form a wide range of chiral 1,3-dienes and pharmaceutically useful vinyloxazolidinones, the chemoselectivity being tightly controlled by a s...

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Detalles Bibliográficos
Autores principales: Brown, Ronald W., Zamani, Farzad, Gardiner, Michael G., Yu, Haibo, Pyne, Stephen G., Hyland, Christopher J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889140/
https://www.ncbi.nlm.nih.gov/pubmed/31827747
http://dx.doi.org/10.1039/c9sc03215k
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author Brown, Ronald W.
Zamani, Farzad
Gardiner, Michael G.
Yu, Haibo
Pyne, Stephen G.
Hyland, Christopher J. T.
author_facet Brown, Ronald W.
Zamani, Farzad
Gardiner, Michael G.
Yu, Haibo
Pyne, Stephen G.
Hyland, Christopher J. T.
author_sort Brown, Ronald W.
collection PubMed
description The divergent reactivity of 5-allenyloxazolidinones has been explored. This novel building block undergoes Pd(0)-catalyzed cross-coupling with boronic acids to form a wide range of chiral 1,3-dienes and pharmaceutically useful vinyloxazolidinones, the chemoselectivity being tightly controlled by a simple switch in additive.
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spelling pubmed-68891402019-12-11 Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones Brown, Ronald W. Zamani, Farzad Gardiner, Michael G. Yu, Haibo Pyne, Stephen G. Hyland, Christopher J. T. Chem Sci Chemistry The divergent reactivity of 5-allenyloxazolidinones has been explored. This novel building block undergoes Pd(0)-catalyzed cross-coupling with boronic acids to form a wide range of chiral 1,3-dienes and pharmaceutically useful vinyloxazolidinones, the chemoselectivity being tightly controlled by a simple switch in additive. Royal Society of Chemistry 2019-08-09 /pmc/articles/PMC6889140/ /pubmed/31827747 http://dx.doi.org/10.1039/c9sc03215k Text en This journal is © The Royal Society of Chemistry 2019 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Brown, Ronald W.
Zamani, Farzad
Gardiner, Michael G.
Yu, Haibo
Pyne, Stephen G.
Hyland, Christopher J. T.
Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones
title Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones
title_full Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones
title_fullStr Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones
title_full_unstemmed Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones
title_short Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones
title_sort divergent pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889140/
https://www.ncbi.nlm.nih.gov/pubmed/31827747
http://dx.doi.org/10.1039/c9sc03215k
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