DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice

DNA methylation regulates cell type-specific gene expression. Here, in a transgenic mouse model, we show that deletion of the gene encoding DNA methyltransferase Dnmt3a in hypothalamic AgRP neurons causes a sedentary phenotype characterized by reduced voluntary exercise and increased adiposity. Whol...

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Detalles Bibliográficos
Autores principales: MacKay, Harry, Scott, C. Anthony, Duryea, Jack D., Baker, Maria S., Laritsky, Eleonora, Elson, Amanda E., Garland Jr., Theodore, Fiorotto, Marta L., Chen, Rui, Li, Yumei, Coarfa, Cristian, Simerly, Richard B., Waterland, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889160/
https://www.ncbi.nlm.nih.gov/pubmed/31792207
http://dx.doi.org/10.1038/s41467-019-13339-3

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