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Systemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapy

BACKGROUND: Protoporphyrin IX (PpIX) gets accumulated preferentially in 5-aminolevulinic acid (5-ALA)-treated cancer cells. Photodynamic therapy (PDT) utilises the accumulated PpIX to trigger cell death by light-induced generation of reactive oxygen species (ROS). We previously demonstrated that onc...

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Detalles Bibliográficos
Autores principales:	Chelakkot, Vipin Shankar, Som, Jayoti, Yoshioka, Ema, Rice, Chantel P., Rutihinda, Suzette G., Hirasawa, Kensuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889170/ https://www.ncbi.nlm.nih.gov/pubmed/31551581 http://dx.doi.org/10.1038/s41416-019-0586-3

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