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Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction

BACKGROUND: Conclusions regarding the association between antithyroid antibodies or thyroid dysfunction and rapid cycling bipolar disorder (RCBD) have been conflicting. Previous studies suggest that the impact of antithyroid antibodies on mental wellbeing seems to be independent of thyroid function....

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Autores principales: Gan, Zhaoyu, Wu, Xiuhua, Chen, Zhongcheng, Liao, Yingtao, Wu, Yingdong, He, Zimeng, Yang, Zhihua, Zhang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889186/
https://www.ncbi.nlm.nih.gov/pubmed/31791284
http://dx.doi.org/10.1186/s12888-019-2354-6
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author Gan, Zhaoyu
Wu, Xiuhua
Chen, Zhongcheng
Liao, Yingtao
Wu, Yingdong
He, Zimeng
Yang, Zhihua
Zhang, Qi
author_facet Gan, Zhaoyu
Wu, Xiuhua
Chen, Zhongcheng
Liao, Yingtao
Wu, Yingdong
He, Zimeng
Yang, Zhihua
Zhang, Qi
author_sort Gan, Zhaoyu
collection PubMed
description BACKGROUND: Conclusions regarding the association between antithyroid antibodies or thyroid dysfunction and rapid cycling bipolar disorder (RCBD) have been conflicting. Previous studies suggest that the impact of antithyroid antibodies on mental wellbeing seems to be independent of thyroid function. Here, we investigated their independent association with RCBD in a large, well-defined population of bipolar disorder (BD). METHODS: Fast serum levels of free thyroxine (FT4), free triiodothyronine (FT3), thyroid Stimulating Hormone (TSH), TPO-abs and Tg-abs were simultaneously measured in 352 patients with BD. Clinical features of BD were collected through semi-structural interview conducted by trained interviewers with background of psychiatric education. RESULTS: Neither hypothyroidism nor hyperthyroidism was significantly associated with RCBD. Both TPO-abs and Tg-abs were significantly related to RCBD, even after controlling for gender, age, marriage status, education, antidepressants treatment, comorbidity of thyroid diseases, and thyroid function (serum levels of FT3, FT4 and TSH). Although TPO-abs and Tg-abs were highly correlated with each other, binary logistic regression with forward LR selected TPO-abs, instead of Tg-abs, to be associated with RCBD. TPO-abs was significantly, independently of Tg-abs, associated with hyperthyroidism, while Tg-abs was marginally significantly related to hypothyroidism at the presence of TPO-abs. CONCLUSION: TPO-abs might be treated as a biomarker of RCBD. Further exploring the underlying mechanism might help understand the nature of RCBD and find out new treatment target for it.
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spelling pubmed-68891862019-12-11 Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction Gan, Zhaoyu Wu, Xiuhua Chen, Zhongcheng Liao, Yingtao Wu, Yingdong He, Zimeng Yang, Zhihua Zhang, Qi BMC Psychiatry Research Article BACKGROUND: Conclusions regarding the association between antithyroid antibodies or thyroid dysfunction and rapid cycling bipolar disorder (RCBD) have been conflicting. Previous studies suggest that the impact of antithyroid antibodies on mental wellbeing seems to be independent of thyroid function. Here, we investigated their independent association with RCBD in a large, well-defined population of bipolar disorder (BD). METHODS: Fast serum levels of free thyroxine (FT4), free triiodothyronine (FT3), thyroid Stimulating Hormone (TSH), TPO-abs and Tg-abs were simultaneously measured in 352 patients with BD. Clinical features of BD were collected through semi-structural interview conducted by trained interviewers with background of psychiatric education. RESULTS: Neither hypothyroidism nor hyperthyroidism was significantly associated with RCBD. Both TPO-abs and Tg-abs were significantly related to RCBD, even after controlling for gender, age, marriage status, education, antidepressants treatment, comorbidity of thyroid diseases, and thyroid function (serum levels of FT3, FT4 and TSH). Although TPO-abs and Tg-abs were highly correlated with each other, binary logistic regression with forward LR selected TPO-abs, instead of Tg-abs, to be associated with RCBD. TPO-abs was significantly, independently of Tg-abs, associated with hyperthyroidism, while Tg-abs was marginally significantly related to hypothyroidism at the presence of TPO-abs. CONCLUSION: TPO-abs might be treated as a biomarker of RCBD. Further exploring the underlying mechanism might help understand the nature of RCBD and find out new treatment target for it. BioMed Central 2019-12-02 /pmc/articles/PMC6889186/ /pubmed/31791284 http://dx.doi.org/10.1186/s12888-019-2354-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Gan, Zhaoyu
Wu, Xiuhua
Chen, Zhongcheng
Liao, Yingtao
Wu, Yingdong
He, Zimeng
Yang, Zhihua
Zhang, Qi
Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction
title Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction
title_full Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction
title_fullStr Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction
title_full_unstemmed Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction
title_short Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction
title_sort rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889186/
https://www.ncbi.nlm.nih.gov/pubmed/31791284
http://dx.doi.org/10.1186/s12888-019-2354-6
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