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Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits

BACKGROUND: Neurochemicals like serotonin and dopamine play crucial roles in human cognitive and emotional functions. Vesicular monoamine transporter 1 (VMAT1) transports monoamine neurotransmitters, and its variant (136Thr) is associated with various psychopathological symptoms and reduced monoamin...

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Detalles Bibliográficos
Autores principales:	Sato, Daiki X., Ishii, Yuu, Nagai, Tomoaki, Ohashi, Kazumasa, Kawata, Masakado
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889191/ https://www.ncbi.nlm.nih.gov/pubmed/31791232 http://dx.doi.org/10.1186/s12862-019-1543-8

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