Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats

BACKGROUND: Neuroinflammation and oxidative stress play important roles in early brain injury following subarachnoid hemorrhage (SAH). This study is the first to show that activation of apelin receptor (APJ) by apelin-13 could reduce endoplasmic reticulum (ER)-stress-associated inflammation and oxid...

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Detalles Bibliográficos
Autores principales: Xu, Weilin, Li, Tao, Gao, Liansheng, Zheng, Jingwei, Yan, Jun, Zhang, Jianmin, Shao, Anwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889224/
https://www.ncbi.nlm.nih.gov/pubmed/31791369
http://dx.doi.org/10.1186/s12974-019-1620-3

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