Molecular mechanisms of congenital heart disease in down syndrome

Down syndrome (DS), as a typical genomic aneuploidy, is a common cause of various birth defects, among which is congenital heart disease (CHD). 40–60% neonates with DS have some kinds of CHD. However, the molecular pathogenic mechanisms of DS associated CHD are still not fully understood. This revie...

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Detalles Bibliográficos
Autores principales: Zhang, Hui, Liu, Lingjuan, Tian, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889238/
https://www.ncbi.nlm.nih.gov/pubmed/31832516
http://dx.doi.org/10.1016/j.gendis.2019.06.007
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author Zhang, Hui
Liu, Lingjuan
Tian, Jie
author_facet Zhang, Hui
Liu, Lingjuan
Tian, Jie
author_sort Zhang, Hui
collection PubMed
description Down syndrome (DS), as a typical genomic aneuploidy, is a common cause of various birth defects, among which is congenital heart disease (CHD). 40–60% neonates with DS have some kinds of CHD. However, the molecular pathogenic mechanisms of DS associated CHD are still not fully understood. This review summarizes available studies on DS associated CHD from seven aspects so as to provide a crucial and updated overview of what we known so far in this domain.
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spelling pubmed-68892382019-12-12 Molecular mechanisms of congenital heart disease in down syndrome Zhang, Hui Liu, Lingjuan Tian, Jie Genes Dis Article Down syndrome (DS), as a typical genomic aneuploidy, is a common cause of various birth defects, among which is congenital heart disease (CHD). 40–60% neonates with DS have some kinds of CHD. However, the molecular pathogenic mechanisms of DS associated CHD are still not fully understood. This review summarizes available studies on DS associated CHD from seven aspects so as to provide a crucial and updated overview of what we known so far in this domain. Chongqing Medical University 2019-07-08 /pmc/articles/PMC6889238/ /pubmed/31832516 http://dx.doi.org/10.1016/j.gendis.2019.06.007 Text en © 2019 Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhang, Hui
Liu, Lingjuan
Tian, Jie
Molecular mechanisms of congenital heart disease in down syndrome
title Molecular mechanisms of congenital heart disease in down syndrome
title_full Molecular mechanisms of congenital heart disease in down syndrome
title_fullStr Molecular mechanisms of congenital heart disease in down syndrome
title_full_unstemmed Molecular mechanisms of congenital heart disease in down syndrome
title_short Molecular mechanisms of congenital heart disease in down syndrome
title_sort molecular mechanisms of congenital heart disease in down syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889238/
https://www.ncbi.nlm.nih.gov/pubmed/31832516
http://dx.doi.org/10.1016/j.gendis.2019.06.007
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