Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer

Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/I...

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Detalles Bibliográficos
Autores principales: Guo, Weijie, Zhou, Binhua P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889240/
https://www.ncbi.nlm.nih.gov/pubmed/31832512
http://dx.doi.org/10.1016/j.gendis.2019.10.005
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author Guo, Weijie
Zhou, Binhua P.
author_facet Guo, Weijie
Zhou, Binhua P.
author_sort Guo, Weijie
collection PubMed
description Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC.
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spelling pubmed-68892402019-12-12 Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer Guo, Weijie Zhou, Binhua P. Genes Dis Article Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC. Chongqing Medical University 2019-10-19 /pmc/articles/PMC6889240/ /pubmed/31832512 http://dx.doi.org/10.1016/j.gendis.2019.10.005 Text en © 2019 Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Guo, Weijie
Zhou, Binhua P.
Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer
title Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer
title_full Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer
title_fullStr Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer
title_full_unstemmed Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer
title_short Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer
title_sort oncometabolite modification of keap1 links gstz1 deficiency with cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889240/
https://www.ncbi.nlm.nih.gov/pubmed/31832512
http://dx.doi.org/10.1016/j.gendis.2019.10.005
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