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3D designed and printed chemical generators for on demand reagent synthesis
Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean thes...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889270/ https://www.ncbi.nlm.nih.gov/pubmed/31792220 http://dx.doi.org/10.1038/s41467-019-13328-6 |
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author | Zalesskiy, Sergey S. Kitson, Philip J. Frei, Przemyslaw Bubliauskas, Andrius Cronin, Leroy |
author_facet | Zalesskiy, Sergey S. Kitson, Philip J. Frei, Przemyslaw Bubliauskas, Andrius Cronin, Leroy |
author_sort | Zalesskiy, Sergey S. |
collection | PubMed |
description | Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean these chemicals can be very expensive to purchase from specialist retailers. Here, we address this problem by developing a cartridge -oriented approach to reactionware-based chemical generators which can easily and reliably produce specific reagents from low-cost precursors, requiring minimal expertise and time to operate, potentially in low infrastructure environments. We developed these chemical generators for four specific targets; transition metal catalyst precursor tris(dibenzylideneacetone)dipalladium(0) [Pd(2)(dba)(3)], oxidising agent Dess-Martin periodinane (DMP), protein photolinking reagent succinimidyl 4,4’-azipentanoate (NHS-diazirine), and the polyoxometalate cluster {P(8)W(48)}. The cartridge synthesis of these materials provides high-quality target compounds in good yields which are suitable for subsequent utilization. |
format | Online Article Text |
id | pubmed-6889270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68892702019-12-04 3D designed and printed chemical generators for on demand reagent synthesis Zalesskiy, Sergey S. Kitson, Philip J. Frei, Przemyslaw Bubliauskas, Andrius Cronin, Leroy Nat Commun Article Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean these chemicals can be very expensive to purchase from specialist retailers. Here, we address this problem by developing a cartridge -oriented approach to reactionware-based chemical generators which can easily and reliably produce specific reagents from low-cost precursors, requiring minimal expertise and time to operate, potentially in low infrastructure environments. We developed these chemical generators for four specific targets; transition metal catalyst precursor tris(dibenzylideneacetone)dipalladium(0) [Pd(2)(dba)(3)], oxidising agent Dess-Martin periodinane (DMP), protein photolinking reagent succinimidyl 4,4’-azipentanoate (NHS-diazirine), and the polyoxometalate cluster {P(8)W(48)}. The cartridge synthesis of these materials provides high-quality target compounds in good yields which are suitable for subsequent utilization. Nature Publishing Group UK 2019-12-02 /pmc/articles/PMC6889270/ /pubmed/31792220 http://dx.doi.org/10.1038/s41467-019-13328-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zalesskiy, Sergey S. Kitson, Philip J. Frei, Przemyslaw Bubliauskas, Andrius Cronin, Leroy 3D designed and printed chemical generators for on demand reagent synthesis |
title | 3D designed and printed chemical generators for on demand reagent synthesis |
title_full | 3D designed and printed chemical generators for on demand reagent synthesis |
title_fullStr | 3D designed and printed chemical generators for on demand reagent synthesis |
title_full_unstemmed | 3D designed and printed chemical generators for on demand reagent synthesis |
title_short | 3D designed and printed chemical generators for on demand reagent synthesis |
title_sort | 3d designed and printed chemical generators for on demand reagent synthesis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889270/ https://www.ncbi.nlm.nih.gov/pubmed/31792220 http://dx.doi.org/10.1038/s41467-019-13328-6 |
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