Senescent cell turnover slows with age providing an explanation for the Gompertz law

A causal factor in mammalian aging is the accumulation of senescent cells (SnCs). SnCs cause chronic inflammation, and removing SnCs decelerates aging in mice. Despite their importance, turnover rates of SnCs are unknown, and their connection to aging dynamics is unclear. Here we use longitudinal Sn...

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Detalles Bibliográficos
Autores principales: Karin, Omer, Agrawal, Amit, Porat, Ziv, Krizhanovsky, Valery, Alon, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889273/
https://www.ncbi.nlm.nih.gov/pubmed/31792199
http://dx.doi.org/10.1038/s41467-019-13192-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889273/
https://www.ncbi.nlm.nih.gov/pubmed/31792199
http://dx.doi.org/10.1038/s41467-019-13192-4

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