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MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells
Tumours manage to survive the ablation of mutant KRAS, despite the development of KRAS-targeted drugs. Here we describe that inhibition of mutant KRAS promotes MEK nuclear localization as an alternative mechanism of KRAS-targeted drugs resistance. Tissue microarray analysis in colon tumours shows th...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889282/ https://www.ncbi.nlm.nih.gov/pubmed/30833665 http://dx.doi.org/10.1038/s41418-019-0309-6 |