Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports

BACKGROUND: Galactomannan index (GMI) at a level higher than 0.5 provides high sensitivity and specificity for the diagnosis of fungal peritonitis. Here, we report the false-positive of GMI in peritoneal dialysis (PD) effluent (PDE) due to Rhodococcus peritonitis in PD patients. CASE PRESENTATION: G...

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Autores principales: Chamroensakchai, Tamonwan, Manuprasert, Wasin, Leelahavanichkul, Asada, Takkavatakarn, Kullaya, Thongbor, Nisa, Jaroenpattrawut, Bunpring, Kanjanabuch, Talerngsak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889329/
https://www.ncbi.nlm.nih.gov/pubmed/31791274
http://dx.doi.org/10.1186/s12882-019-1642-1
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author Chamroensakchai, Tamonwan
Manuprasert, Wasin
Leelahavanichkul, Asada
Takkavatakarn, Kullaya
Thongbor, Nisa
Jaroenpattrawut, Bunpring
Kanjanabuch, Talerngsak
author_facet Chamroensakchai, Tamonwan
Manuprasert, Wasin
Leelahavanichkul, Asada
Takkavatakarn, Kullaya
Thongbor, Nisa
Jaroenpattrawut, Bunpring
Kanjanabuch, Talerngsak
author_sort Chamroensakchai, Tamonwan
collection PubMed
description BACKGROUND: Galactomannan index (GMI) at a level higher than 0.5 provides high sensitivity and specificity for the diagnosis of fungal peritonitis. Here, we report the false-positive of GMI in peritoneal dialysis (PD) effluent (PDE) due to Rhodococcus peritonitis in PD patients. CASE PRESENTATION: GMI in PDE of case #1 and case #2 were 1.53 and 0.76, respectively, while serum GMI of both cases was less than 0.5. In addition, GMI from the specimens obtained directly from the stationary phase of Rhodococcus colonies were 1.27 and 1.56, which were isolated from case #1 and #2, accordingly. CONCLUSION: High GMI in PDE of PD patients is not specific just for fungal infections but may also be secondary to other infections, such as Rhodococcus spp., especially in endemic areas.
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spelling pubmed-68893292019-12-11 Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports Chamroensakchai, Tamonwan Manuprasert, Wasin Leelahavanichkul, Asada Takkavatakarn, Kullaya Thongbor, Nisa Jaroenpattrawut, Bunpring Kanjanabuch, Talerngsak BMC Nephrol Case Report BACKGROUND: Galactomannan index (GMI) at a level higher than 0.5 provides high sensitivity and specificity for the diagnosis of fungal peritonitis. Here, we report the false-positive of GMI in peritoneal dialysis (PD) effluent (PDE) due to Rhodococcus peritonitis in PD patients. CASE PRESENTATION: GMI in PDE of case #1 and case #2 were 1.53 and 0.76, respectively, while serum GMI of both cases was less than 0.5. In addition, GMI from the specimens obtained directly from the stationary phase of Rhodococcus colonies were 1.27 and 1.56, which were isolated from case #1 and #2, accordingly. CONCLUSION: High GMI in PDE of PD patients is not specific just for fungal infections but may also be secondary to other infections, such as Rhodococcus spp., especially in endemic areas. BioMed Central 2019-12-02 /pmc/articles/PMC6889329/ /pubmed/31791274 http://dx.doi.org/10.1186/s12882-019-1642-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Chamroensakchai, Tamonwan
Manuprasert, Wasin
Leelahavanichkul, Asada
Takkavatakarn, Kullaya
Thongbor, Nisa
Jaroenpattrawut, Bunpring
Kanjanabuch, Talerngsak
Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports
title Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports
title_full Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports
title_fullStr Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports
title_full_unstemmed Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports
title_short Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports
title_sort rhodococcus induced false-positive galactomannan (gm), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889329/
https://www.ncbi.nlm.nih.gov/pubmed/31791274
http://dx.doi.org/10.1186/s12882-019-1642-1
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