S-15 in combination of Akt inhibitor promotes the expansion of CD45RA(−)CCR7(+) tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1(+)Tim-3(+) cells as well as regulatory T cells

BACKGROUND: Autologous tumor-infiltrating lymphocytes (Tils) immunotherapy is a promising treatment in patients with advanced hepatocellular cancer. Although Tils treatment has shown great promise, their persistence and the efficacy after adoptive-transfer are insufficient and remain a challenge. St...

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Detalles Bibliográficos
Autores principales: Xu, Benling, Yuan, Long, Chen, Guangyu, Li, Tiepeng, Zhou, Jinxue, Zhang, Chengjuan, Qin, Peng, Muthana, Musleh M., Wang, Shengdian, Du, Xuexiang, Gao, Quanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889332/
https://www.ncbi.nlm.nih.gov/pubmed/31827396
http://dx.doi.org/10.1186/s12935-019-1043-3

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