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Identification of the amino acid residue responsible for the myricetin sensitivity of human proton-coupled folate transporter
Human proton-coupled folate transporter (hPCFT/SLC46A1) has recently been found to be inhibited by myricetin by a sustained mechanism, raising a concern that the inhibition might lead to malabsorption of folates in the intestine, where hPCFT works for their epithelial uptake. However, rat PCFT (rPCF...
Autores principales: | Yamashiro, Takahiro, Yasujima, Tomoya, Ohta, Kinya, Inoue, Katsuhisa, Yuasa, Hiroaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889420/ https://www.ncbi.nlm.nih.gov/pubmed/31792273 http://dx.doi.org/10.1038/s41598-019-54367-9 |
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