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Conditional crude probabilities of death for English cancer patients

BACKGROUND: Cancer survival statistics are typically reported by using measures discounting the impact of other-cause mortality, such as net survival. This is a hypothetical measure and is interpreted as excluding the possibility of cancer patients dying from other causes. Crude probability of death...

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Autores principales: Wong, Kwok F., Lambert, Paul C., Mozumder, Sarwar I., Broggio, John, Rutherford, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889443/
https://www.ncbi.nlm.nih.gov/pubmed/31601960
http://dx.doi.org/10.1038/s41416-019-0597-0
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author Wong, Kwok F.
Lambert, Paul C.
Mozumder, Sarwar I.
Broggio, John
Rutherford, Mark J.
author_facet Wong, Kwok F.
Lambert, Paul C.
Mozumder, Sarwar I.
Broggio, John
Rutherford, Mark J.
author_sort Wong, Kwok F.
collection PubMed
description BACKGROUND: Cancer survival statistics are typically reported by using measures discounting the impact of other-cause mortality, such as net survival. This is a hypothetical measure and is interpreted as excluding the possibility of cancer patients dying from other causes. Crude probability of death partitions the all-cause probability of death into deaths from cancer and other causes. METHODS: The National Cancer Registration and Analysis Service is the single cancer registry for England. In 2006–2015, 1,590,477 malignant tumours were diagnosed for breast, colorectal, lung, melanoma and prostate cancer in adults. We used a relative survival framework, with a period approach, providing estimates for up to 10-year survival. Mortality was partitioned into deaths due to cancer or other causes. Unconditional and conditional (on surviving 1-years and 5-years) crude probability of death were estimated for the five cancers. RESULTS: Elderly patients who survived for a longer period before dying were more likely to die from other causes of death (except for lung cancer). For younger patients, deaths were almost entirely due to the cancer. CONCLUSION: There are different measures of survival, each with their own strengths and limitations. Careful choices of survival measures are needed for specific scenarios to maximise the understanding of the data.
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spelling pubmed-68894432020-10-11 Conditional crude probabilities of death for English cancer patients Wong, Kwok F. Lambert, Paul C. Mozumder, Sarwar I. Broggio, John Rutherford, Mark J. Br J Cancer Article BACKGROUND: Cancer survival statistics are typically reported by using measures discounting the impact of other-cause mortality, such as net survival. This is a hypothetical measure and is interpreted as excluding the possibility of cancer patients dying from other causes. Crude probability of death partitions the all-cause probability of death into deaths from cancer and other causes. METHODS: The National Cancer Registration and Analysis Service is the single cancer registry for England. In 2006–2015, 1,590,477 malignant tumours were diagnosed for breast, colorectal, lung, melanoma and prostate cancer in adults. We used a relative survival framework, with a period approach, providing estimates for up to 10-year survival. Mortality was partitioned into deaths due to cancer or other causes. Unconditional and conditional (on surviving 1-years and 5-years) crude probability of death were estimated for the five cancers. RESULTS: Elderly patients who survived for a longer period before dying were more likely to die from other causes of death (except for lung cancer). For younger patients, deaths were almost entirely due to the cancer. CONCLUSION: There are different measures of survival, each with their own strengths and limitations. Careful choices of survival measures are needed for specific scenarios to maximise the understanding of the data. Nature Publishing Group UK 2019-10-11 2019-11-12 /pmc/articles/PMC6889443/ /pubmed/31601960 http://dx.doi.org/10.1038/s41416-019-0597-0 Text en © The Author(s), under exclusive licence to Cancer Research UK 2019 https://creativecommons.org/licenses/by/4.0/This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
spellingShingle Article
Wong, Kwok F.
Lambert, Paul C.
Mozumder, Sarwar I.
Broggio, John
Rutherford, Mark J.
Conditional crude probabilities of death for English cancer patients
title Conditional crude probabilities of death for English cancer patients
title_full Conditional crude probabilities of death for English cancer patients
title_fullStr Conditional crude probabilities of death for English cancer patients
title_full_unstemmed Conditional crude probabilities of death for English cancer patients
title_short Conditional crude probabilities of death for English cancer patients
title_sort conditional crude probabilities of death for english cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889443/
https://www.ncbi.nlm.nih.gov/pubmed/31601960
http://dx.doi.org/10.1038/s41416-019-0597-0
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