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Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran

BACKGROUND: Viral hepatitis is a global public health problem affecting millions of people worldwide, causing thousands of deaths due to acute and persistent infection, cirrhosis, and liver cancer. Providing updated serologic data can improve both surveillance and disease control programs. This stud...

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Autores principales: Behzadi, Mohammad Amin, Leyva-Grado, Victor Hugo, Namayandeh, Mandana, Ziyaeyan, Atoosa, Feyznezhad, Roya, Dorzaban, Hedayat, Jamalidoust, Marzieh, Ziyaeyan, Mazyar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889522/
https://www.ncbi.nlm.nih.gov/pubmed/31795979
http://dx.doi.org/10.1186/s12879-019-4661-4
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author Behzadi, Mohammad Amin
Leyva-Grado, Victor Hugo
Namayandeh, Mandana
Ziyaeyan, Atoosa
Feyznezhad, Roya
Dorzaban, Hedayat
Jamalidoust, Marzieh
Ziyaeyan, Mazyar
author_facet Behzadi, Mohammad Amin
Leyva-Grado, Victor Hugo
Namayandeh, Mandana
Ziyaeyan, Atoosa
Feyznezhad, Roya
Dorzaban, Hedayat
Jamalidoust, Marzieh
Ziyaeyan, Mazyar
author_sort Behzadi, Mohammad Amin
collection PubMed
description BACKGROUND: Viral hepatitis is a global public health problem affecting millions of people worldwide, causing thousands of deaths due to acute and persistent infection, cirrhosis, and liver cancer. Providing updated serologic data can improve both surveillance and disease control programs. This study is aimed to determine the seroprevalence of markers for viral hepatitis (A, B, C, D and E) and the epidemiology of such infections in the general population of southern Iran’s Hormozgan province. METHODS: Between 2016 and 2017, a total of 562 individuals with ages ranging from 1 to 86 years, who visited governmental public laboratories for routine check-ups, were tested for the presence of serological markers to hepatitis virus types A to E using enzyme-linked immunosorbent assays. RESULTS: The overall anti-hepatitis A virus (HAV) antibody seroprevalence was 93.2% (524/562). The prevalence of anti-hepatitis E virus (HEV) antibodies was 15.8% (89/562) among which 1.6% (9/562) of the seropositive individuals also had evidence of recent exposure to the virus (IgM positivity). Two and a half percent (14/562) were positive for hepatitis B surface (HBs) antigen, whereas 11.6% (65/562) tested positive for anti-hepatitis B core (HBc) antibodies. Among anti-HBc positive patients, 11% (7/65) had HBs Ag and 5% (3/65) were positive for anti-hepatitis D virus (HDV) antibodies. The prevalence of anti-hepatitis C virus (HCV) antibodies was 0.7% (4/562). The seroprevalence of anti-HAV, HEV IgG, anti-HBc antibodies, and HBs Ag increased with age. CONCLUSION: The present study confirms a high seroprevalence of HAV infection among the examined population and reveals high levels of endemicity for HEV in the region. Planned vaccination policies against HAV should be considered in all parts of Iran. In addition, improvements on public sanitation and hygiene management of drinking water sources for the studied area are recommended.
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spelling pubmed-68895222019-12-11 Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran Behzadi, Mohammad Amin Leyva-Grado, Victor Hugo Namayandeh, Mandana Ziyaeyan, Atoosa Feyznezhad, Roya Dorzaban, Hedayat Jamalidoust, Marzieh Ziyaeyan, Mazyar BMC Infect Dis Research Article BACKGROUND: Viral hepatitis is a global public health problem affecting millions of people worldwide, causing thousands of deaths due to acute and persistent infection, cirrhosis, and liver cancer. Providing updated serologic data can improve both surveillance and disease control programs. This study is aimed to determine the seroprevalence of markers for viral hepatitis (A, B, C, D and E) and the epidemiology of such infections in the general population of southern Iran’s Hormozgan province. METHODS: Between 2016 and 2017, a total of 562 individuals with ages ranging from 1 to 86 years, who visited governmental public laboratories for routine check-ups, were tested for the presence of serological markers to hepatitis virus types A to E using enzyme-linked immunosorbent assays. RESULTS: The overall anti-hepatitis A virus (HAV) antibody seroprevalence was 93.2% (524/562). The prevalence of anti-hepatitis E virus (HEV) antibodies was 15.8% (89/562) among which 1.6% (9/562) of the seropositive individuals also had evidence of recent exposure to the virus (IgM positivity). Two and a half percent (14/562) were positive for hepatitis B surface (HBs) antigen, whereas 11.6% (65/562) tested positive for anti-hepatitis B core (HBc) antibodies. Among anti-HBc positive patients, 11% (7/65) had HBs Ag and 5% (3/65) were positive for anti-hepatitis D virus (HDV) antibodies. The prevalence of anti-hepatitis C virus (HCV) antibodies was 0.7% (4/562). The seroprevalence of anti-HAV, HEV IgG, anti-HBc antibodies, and HBs Ag increased with age. CONCLUSION: The present study confirms a high seroprevalence of HAV infection among the examined population and reveals high levels of endemicity for HEV in the region. Planned vaccination policies against HAV should be considered in all parts of Iran. In addition, improvements on public sanitation and hygiene management of drinking water sources for the studied area are recommended. BioMed Central 2019-12-03 /pmc/articles/PMC6889522/ /pubmed/31795979 http://dx.doi.org/10.1186/s12879-019-4661-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Behzadi, Mohammad Amin
Leyva-Grado, Victor Hugo
Namayandeh, Mandana
Ziyaeyan, Atoosa
Feyznezhad, Roya
Dorzaban, Hedayat
Jamalidoust, Marzieh
Ziyaeyan, Mazyar
Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran
title Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran
title_full Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran
title_fullStr Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran
title_full_unstemmed Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran
title_short Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran
title_sort seroprevalence of viral hepatitis a, b, c, d and e viruses in the hormozgan province southern iran
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889522/
https://www.ncbi.nlm.nih.gov/pubmed/31795979
http://dx.doi.org/10.1186/s12879-019-4661-4
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