Cargando…
Regulation of CFTR Bicarbonate Channel Activity by WNK1: Implications for Pancreatitis and CFTR-Related Disorders
BACKGRAOUD & AIMS: Aberrant epithelial bicarbonate (HCO(3)(−)) secretion caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is associated with several diseases including cystic fibrosis and pancreatitis. Dynamically regulated ion channel activity and anion...
Autores principales: | Kim, Yonjung, Jun, Ikhyun, Shin, Dong Hoon, Yoon, Jihoon G., Piao, He, Jung, Jinsei, Park, Hyun Woo, Cheng, Mary Hongying, Bahar, Ivet, Whitcomb, David C., Lee, Min Goo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889609/ https://www.ncbi.nlm.nih.gov/pubmed/31561038 http://dx.doi.org/10.1016/j.jcmgh.2019.09.003 |
Ejemplares similares
-
Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis
por: LaRusch, Jessica, et al.
Publicado: (2014) -
CFTR Functions as a Bicarbonate Channel in Pancreatic Duct Cells
por: Ishiguro, Hiroshi, et al.
Publicado: (2009) -
Bicarbonate defective CFTR variants increase risk for chronic pancreatitis: A meta-analysis
por: Berke, Gergő, et al.
Publicado: (2022) -
Correctors modify the bicarbonate permeability of F508del-CFTR
por: Fiore, Michele, et al.
Publicado: (2020) -
Editorial Focus: CFTR‐dependent bicarbonate secretion by Calu‐3 cells
por: Rubenstein, Ronald C.
Publicado: (2018)