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Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry

BACKGROUND: Peptides corresponding to N- and C-terminal heptad repeat regions (HR1 and HR2, respectively) of gp41 can inhibit HIV-1 infection in a dominant negative manner by interfering with refolding of the viral HR1 and HR2 to form a six-helix bundle (6HB) that induces fusion between viral and ho...

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Detalles Bibliográficos
Autores principales:	Yuan, Chen, Wang, Jia-Ye, Zhao, Hai-Jiao, Li, Yan, Li, Di, Ling, Hong, Zhuang, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889725/ https://www.ncbi.nlm.nih.gov/pubmed/31796053 http://dx.doi.org/10.1186/s12977-019-0496-8

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