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Hydrogel Microfilaments toward Intradermal Health Monitoring

Digital health promises a paradigm shift for medicine where biomarkers in individuals are continuously monitored to improve diagnosis and treatment of disease. To that end, a technology for minimally invasive quantification of endogenous analytes in bodily fluids will be required. Here, we describe...

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Detalles Bibliográficos
Autores principales: Tejavibulya, Nalin, Colburn, David A.M., Marcogliese, Francis A., Yang, Kyung-Ae, Guo, Vincent, Chowdhury, Shilpika, Stojanovic, Milan N., Sia, Samuel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889782/
https://www.ncbi.nlm.nih.gov/pubmed/31698247
http://dx.doi.org/10.1016/j.isci.2019.10.036
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author Tejavibulya, Nalin
Colburn, David A.M.
Marcogliese, Francis A.
Yang, Kyung-Ae
Guo, Vincent
Chowdhury, Shilpika
Stojanovic, Milan N.
Sia, Samuel K.
author_facet Tejavibulya, Nalin
Colburn, David A.M.
Marcogliese, Francis A.
Yang, Kyung-Ae
Guo, Vincent
Chowdhury, Shilpika
Stojanovic, Milan N.
Sia, Samuel K.
author_sort Tejavibulya, Nalin
collection PubMed
description Digital health promises a paradigm shift for medicine where biomarkers in individuals are continuously monitored to improve diagnosis and treatment of disease. To that end, a technology for minimally invasive quantification of endogenous analytes in bodily fluids will be required. Here, we describe a strategy for designing and fabricating hydrogel microfilaments that can penetrate the skin while allowing for optical fluorescence sensing. The polyacrylamide formulation was selected to provide high elastic modulus in the dehydrated state and optical transparency in the hydrated state. The microfilaments can be covalently tethered to a fluorescent aptamer to enable functional sensing. The microfilament array can penetrate the skin with low pain and without breaking, contact the dermal interstitial fluid, and be easily removed from the skin. In the future, hydrogel microfilaments could be integrated with a wearable fluorometer to serve as a platform for continuous, minimally invasive monitoring of intradermal biomarkers.
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spelling pubmed-68897822019-12-11 Hydrogel Microfilaments toward Intradermal Health Monitoring Tejavibulya, Nalin Colburn, David A.M. Marcogliese, Francis A. Yang, Kyung-Ae Guo, Vincent Chowdhury, Shilpika Stojanovic, Milan N. Sia, Samuel K. iScience Article Digital health promises a paradigm shift for medicine where biomarkers in individuals are continuously monitored to improve diagnosis and treatment of disease. To that end, a technology for minimally invasive quantification of endogenous analytes in bodily fluids will be required. Here, we describe a strategy for designing and fabricating hydrogel microfilaments that can penetrate the skin while allowing for optical fluorescence sensing. The polyacrylamide formulation was selected to provide high elastic modulus in the dehydrated state and optical transparency in the hydrated state. The microfilaments can be covalently tethered to a fluorescent aptamer to enable functional sensing. The microfilament array can penetrate the skin with low pain and without breaking, contact the dermal interstitial fluid, and be easily removed from the skin. In the future, hydrogel microfilaments could be integrated with a wearable fluorometer to serve as a platform for continuous, minimally invasive monitoring of intradermal biomarkers. Elsevier 2019-10-23 /pmc/articles/PMC6889782/ /pubmed/31698247 http://dx.doi.org/10.1016/j.isci.2019.10.036 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Tejavibulya, Nalin
Colburn, David A.M.
Marcogliese, Francis A.
Yang, Kyung-Ae
Guo, Vincent
Chowdhury, Shilpika
Stojanovic, Milan N.
Sia, Samuel K.
Hydrogel Microfilaments toward Intradermal Health Monitoring
title Hydrogel Microfilaments toward Intradermal Health Monitoring
title_full Hydrogel Microfilaments toward Intradermal Health Monitoring
title_fullStr Hydrogel Microfilaments toward Intradermal Health Monitoring
title_full_unstemmed Hydrogel Microfilaments toward Intradermal Health Monitoring
title_short Hydrogel Microfilaments toward Intradermal Health Monitoring
title_sort hydrogel microfilaments toward intradermal health monitoring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889782/
https://www.ncbi.nlm.nih.gov/pubmed/31698247
http://dx.doi.org/10.1016/j.isci.2019.10.036
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