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The brain's functional connectome in young children with prenatal alcohol exposure
Prenatal alcohol exposure (PAE) can lead to altered brain function and structure, as well as lifelong cognitive, behavioral, and mental health difficulties. Previous research has shown reduced brain network efficiency in older children and adolescents with PAE, but no imaging studies have examined b...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889793/ https://www.ncbi.nlm.nih.gov/pubmed/31795047 http://dx.doi.org/10.1016/j.nicl.2019.102082 |
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author | Long, Xiangyu Kar, Preeti Gibbard, Ben Tortorelli, Christina Lebel, Catherine |
author_facet | Long, Xiangyu Kar, Preeti Gibbard, Ben Tortorelli, Christina Lebel, Catherine |
author_sort | Long, Xiangyu |
collection | PubMed |
description | Prenatal alcohol exposure (PAE) can lead to altered brain function and structure, as well as lifelong cognitive, behavioral, and mental health difficulties. Previous research has shown reduced brain network efficiency in older children and adolescents with PAE, but no imaging studies have examined brain differences in young children with PAE, at an age when cognitive and behavioral problems often first become apparent. The present study aimed to investigate the brain's functional connectome in young children with PAE using passive viewing fMRI. We analyzed 34 datasets from 26 children with PAE aged 2–7 years and 215 datasets from 87 unexposed typically-developing children in the same age range. The whole brain functional connectome was constructed using functional connectivity analysis across 90 regions for each dataset. We examined intra- and inter-participant stability of the functional connectome, graph theoretical measurements, and their correlations with age. Children with PAE had similar inter- and intra-participant stability to controls. However, children with PAE, but not controls, showed increasing intra-participant stability with age, suggesting a lack of variability of intrinsic brain activity over time. Inter-participant stability increased with age in controls but not in children with PAE, indicating more variability of brain function across the PAE population. Global graph metrics were similar between children with PAE and controls, in line with previous studies in older children. This study characterizes the functional connectome in young children with PAE for the first time, suggesting that the increased brain variability seen in older children develops early in childhood, when participants with PAE fail to show the expected age-related increases in inter-individual stability. |
format | Online Article Text |
id | pubmed-6889793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68897932019-12-12 The brain's functional connectome in young children with prenatal alcohol exposure Long, Xiangyu Kar, Preeti Gibbard, Ben Tortorelli, Christina Lebel, Catherine Neuroimage Clin Regular Article Prenatal alcohol exposure (PAE) can lead to altered brain function and structure, as well as lifelong cognitive, behavioral, and mental health difficulties. Previous research has shown reduced brain network efficiency in older children and adolescents with PAE, but no imaging studies have examined brain differences in young children with PAE, at an age when cognitive and behavioral problems often first become apparent. The present study aimed to investigate the brain's functional connectome in young children with PAE using passive viewing fMRI. We analyzed 34 datasets from 26 children with PAE aged 2–7 years and 215 datasets from 87 unexposed typically-developing children in the same age range. The whole brain functional connectome was constructed using functional connectivity analysis across 90 regions for each dataset. We examined intra- and inter-participant stability of the functional connectome, graph theoretical measurements, and their correlations with age. Children with PAE had similar inter- and intra-participant stability to controls. However, children with PAE, but not controls, showed increasing intra-participant stability with age, suggesting a lack of variability of intrinsic brain activity over time. Inter-participant stability increased with age in controls but not in children with PAE, indicating more variability of brain function across the PAE population. Global graph metrics were similar between children with PAE and controls, in line with previous studies in older children. This study characterizes the functional connectome in young children with PAE for the first time, suggesting that the increased brain variability seen in older children develops early in childhood, when participants with PAE fail to show the expected age-related increases in inter-individual stability. Elsevier 2019-11-09 /pmc/articles/PMC6889793/ /pubmed/31795047 http://dx.doi.org/10.1016/j.nicl.2019.102082 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Long, Xiangyu Kar, Preeti Gibbard, Ben Tortorelli, Christina Lebel, Catherine The brain's functional connectome in young children with prenatal alcohol exposure |
title | The brain's functional connectome in young children with prenatal alcohol exposure |
title_full | The brain's functional connectome in young children with prenatal alcohol exposure |
title_fullStr | The brain's functional connectome in young children with prenatal alcohol exposure |
title_full_unstemmed | The brain's functional connectome in young children with prenatal alcohol exposure |
title_short | The brain's functional connectome in young children with prenatal alcohol exposure |
title_sort | brain's functional connectome in young children with prenatal alcohol exposure |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889793/ https://www.ncbi.nlm.nih.gov/pubmed/31795047 http://dx.doi.org/10.1016/j.nicl.2019.102082 |
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