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Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B(−/−) Mice
The neural substrates and pathophysiological mechanisms underlying the onset of cognitive and motor deficits in autism spectrum disorders (ASDs) remain unclear. Mutations in ASD-associated SHANK3 in mice (Shank3B(−/−)) result in the accelerated maturation of corticostriatal circuits during the secon...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889826/ https://www.ncbi.nlm.nih.gov/pubmed/31722214 http://dx.doi.org/10.1016/j.celrep.2019.10.021 |