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CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA

PURPOSE: To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions. METHODS: The enhanced depth imaging optical coherence tomogr...

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Autores principales: Egawa, Mariko, Mitamura, Yoshinori, Niki, Masanori, Sano, Hiroki, Miura, Gen, Chiba, Akihiro, Yamamoto, Shuichi, Sonoda, Shozo, Sakamoto, Taiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Retina 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889909/
https://www.ncbi.nlm.nih.gov/pubmed/30106795
http://dx.doi.org/10.1097/IAE.0000000000002285
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author Egawa, Mariko
Mitamura, Yoshinori
Niki, Masanori
Sano, Hiroki
Miura, Gen
Chiba, Akihiro
Yamamoto, Shuichi
Sonoda, Shozo
Sakamoto, Taiji
author_facet Egawa, Mariko
Mitamura, Yoshinori
Niki, Masanori
Sano, Hiroki
Miura, Gen
Chiba, Akihiro
Yamamoto, Shuichi
Sonoda, Shozo
Sakamoto, Taiji
author_sort Egawa, Mariko
collection PubMed
description PURPOSE: To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions. METHODS: The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length–matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500-µm width were measured. The inner choroid included the choriocapillaris and medium vessel layer, and the outer choroid included the larger vessel layer. RESULTS: In the inner choroid, the luminal area and the ratio of luminal/total choroidal area (L/C ratio) were significantly smaller in RP than in controls (P = 0.010, P < 0.001, respectively), whereas the stromal area was not significantly different (P = 0.114). The inner choroidal L/C ratio was significantly correlated with the best-corrected visual acuity, mean deviation, foveal sensitivity, width of the ellipsoid zone, and central foveal thickness in RP after adjusting for the axial length, age, and sex (all P < 0.005). CONCLUSION: The significant correlations between the inner choroidal structures and the visual functions and retinal structures indicate that the choroidal structures are altered in association with the progression of RP.
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spelling pubmed-68899092020-01-22 CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA Egawa, Mariko Mitamura, Yoshinori Niki, Masanori Sano, Hiroki Miura, Gen Chiba, Akihiro Yamamoto, Shuichi Sonoda, Shozo Sakamoto, Taiji Retina Original Study PURPOSE: To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions. METHODS: The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length–matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500-µm width were measured. The inner choroid included the choriocapillaris and medium vessel layer, and the outer choroid included the larger vessel layer. RESULTS: In the inner choroid, the luminal area and the ratio of luminal/total choroidal area (L/C ratio) were significantly smaller in RP than in controls (P = 0.010, P < 0.001, respectively), whereas the stromal area was not significantly different (P = 0.114). The inner choroidal L/C ratio was significantly correlated with the best-corrected visual acuity, mean deviation, foveal sensitivity, width of the ellipsoid zone, and central foveal thickness in RP after adjusting for the axial length, age, and sex (all P < 0.005). CONCLUSION: The significant correlations between the inner choroidal structures and the visual functions and retinal structures indicate that the choroidal structures are altered in association with the progression of RP. Retina 2019-12 2018-08-10 /pmc/articles/PMC6889909/ /pubmed/30106795 http://dx.doi.org/10.1097/IAE.0000000000002285 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Study
Egawa, Mariko
Mitamura, Yoshinori
Niki, Masanori
Sano, Hiroki
Miura, Gen
Chiba, Akihiro
Yamamoto, Shuichi
Sonoda, Shozo
Sakamoto, Taiji
CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA
title CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA
title_full CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA
title_fullStr CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA
title_full_unstemmed CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA
title_short CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA
title_sort correlations between choroidal structures and visual functions in eyes with retinitis pigmentosa
topic Original Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889909/
https://www.ncbi.nlm.nih.gov/pubmed/30106795
http://dx.doi.org/10.1097/IAE.0000000000002285
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