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HMGB1 participates in LPS-induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE/NF-κB signaling pathways

High mobility group box 1 (HMGB1), a crucial proinflammatory cytokine, was reported to activate the absent in melanoma 2 (AIM2) inflammasome, which are both essential in acute lung injury (ALI). However, their interaction mechanism has remained elusive. Macrophages are known to express the AIM2 infl...

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Detalles Bibliográficos
Autores principales:	Wang, Jing, Li, Ruiting, Peng, Zhiyong, Hu, Bo, Rao, Xin, Li, Jianguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889921/ https://www.ncbi.nlm.nih.gov/pubmed/31746367 http://dx.doi.org/10.3892/ijmm.2019.4402

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