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Transcription-induced formation of extrachromosomal DNA during yeast ageing

Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid and extensive gene copy number variation and is implicated in the pathology of cancer and ageing. Here, we demonstrate that yeast aged under environmental copper accumulate high levels of eccDNA containing the co...

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Detalles Bibliográficos
Autores principales:	Hull, Ryan M., King, Michelle, Pizza, Grazia, Krueger, Felix, Vergara, Xabier, Houseley, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890164/ https://www.ncbi.nlm.nih.gov/pubmed/31794573 http://dx.doi.org/10.1371/journal.pbio.3000471

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