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Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM

AIM: Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesit...

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Autores principales: Yen, I-Weng, Lee, Chien-Nan, Lin, Ming-Wei, Fan, Kang-Chih, Wei, Jung-Nan, Chen, Kuan-Yu, Chen, Szu-Chi, Tai, Yi-Yun, Kuo, Chun-Heng, Lin, Chia-Hung, Hsu, Chih-Yao, Chuang, Lee-Ming, Lin, Shin-Yu, Li, Hung-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890240/
https://www.ncbi.nlm.nih.gov/pubmed/31794594
http://dx.doi.org/10.1371/journal.pone.0225978
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author Yen, I-Weng
Lee, Chien-Nan
Lin, Ming-Wei
Fan, Kang-Chih
Wei, Jung-Nan
Chen, Kuan-Yu
Chen, Szu-Chi
Tai, Yi-Yun
Kuo, Chun-Heng
Lin, Chia-Hung
Hsu, Chih-Yao
Chuang, Lee-Ming
Lin, Shin-Yu
Li, Hung-Yuan
author_facet Yen, I-Weng
Lee, Chien-Nan
Lin, Ming-Wei
Fan, Kang-Chih
Wei, Jung-Nan
Chen, Kuan-Yu
Chen, Szu-Chi
Tai, Yi-Yun
Kuo, Chun-Heng
Lin, Chia-Hung
Hsu, Chih-Yao
Chuang, Lee-Ming
Lin, Shin-Yu
Li, Hung-Yuan
author_sort Yen, I-Weng
collection PubMed
description AIM: Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM in this cohort study. METHODS: Total 527 women who visited National Taiwan University Hospital for prenatal care in between November 2013 to April 2018 were enrolled. Risk factors of GDM in the first prenatal visit (FPV) were recorded. Overweight/obesity was defined if body mass index ≥24 kg/m(2). GDM was diagnosed from the result of a 75g oral glucose tolerance test in 24–28 gestational weeks. RESULTS: Overweight/obesity was associated with clustering of metabolic risk factors of GDM, including high fasting plasma glucose, high HbA1c, insulin resistance, high plasma triglyceride and elevated blood pressure in FPV (p<0.05). There was a positive relationship between the number of metabolic risk factors and the incidence of GDM (p <0.05). The odds ratios of HbA1c and diastolic blood pressure were higher in overweight/obese women, compared with those in normal-weight women. CONCLUSIONS: Overweight/obesity is associated with clustering of metabolic risk factors in early pregnancy, which is correlated with higher risk of GDM. Our findings suggest that metabolic risk factors during early pregnancy should be evaluated in overweight/obese women.
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spelling pubmed-68902402019-12-13 Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM Yen, I-Weng Lee, Chien-Nan Lin, Ming-Wei Fan, Kang-Chih Wei, Jung-Nan Chen, Kuan-Yu Chen, Szu-Chi Tai, Yi-Yun Kuo, Chun-Heng Lin, Chia-Hung Hsu, Chih-Yao Chuang, Lee-Ming Lin, Shin-Yu Li, Hung-Yuan PLoS One Research Article AIM: Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM in this cohort study. METHODS: Total 527 women who visited National Taiwan University Hospital for prenatal care in between November 2013 to April 2018 were enrolled. Risk factors of GDM in the first prenatal visit (FPV) were recorded. Overweight/obesity was defined if body mass index ≥24 kg/m(2). GDM was diagnosed from the result of a 75g oral glucose tolerance test in 24–28 gestational weeks. RESULTS: Overweight/obesity was associated with clustering of metabolic risk factors of GDM, including high fasting plasma glucose, high HbA1c, insulin resistance, high plasma triglyceride and elevated blood pressure in FPV (p<0.05). There was a positive relationship between the number of metabolic risk factors and the incidence of GDM (p <0.05). The odds ratios of HbA1c and diastolic blood pressure were higher in overweight/obese women, compared with those in normal-weight women. CONCLUSIONS: Overweight/obesity is associated with clustering of metabolic risk factors in early pregnancy, which is correlated with higher risk of GDM. Our findings suggest that metabolic risk factors during early pregnancy should be evaluated in overweight/obese women. Public Library of Science 2019-12-03 /pmc/articles/PMC6890240/ /pubmed/31794594 http://dx.doi.org/10.1371/journal.pone.0225978 Text en © 2019 Yen et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yen, I-Weng
Lee, Chien-Nan
Lin, Ming-Wei
Fan, Kang-Chih
Wei, Jung-Nan
Chen, Kuan-Yu
Chen, Szu-Chi
Tai, Yi-Yun
Kuo, Chun-Heng
Lin, Chia-Hung
Hsu, Chih-Yao
Chuang, Lee-Ming
Lin, Shin-Yu
Li, Hung-Yuan
Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
title Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
title_full Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
title_fullStr Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
title_full_unstemmed Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
title_short Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
title_sort overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of gdm
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890240/
https://www.ncbi.nlm.nih.gov/pubmed/31794594
http://dx.doi.org/10.1371/journal.pone.0225978
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