A siRNA mediated hepatic dpp4 knockdown affects lipid, but not glucose metabolism in diabetic mice

Systemic inhibition of dipeptidyl peptidase 4 (dpp4) represents an effective and established treatment option for type 2 diabetes (T2D). The current study investigated in mice if a liver selective knock-down of dpp4 by therapeutic siRNAs could be a novel, similarly effective treatment option for T2D...

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Detalles Bibliográficos
Autores principales: Görgens, Sven Wolfgang, Jahn-Hofmann, Kerstin, Bangari, Dinesh, Cummings, Sheila, Metz-Weidmann, Christiane, Schwahn, Uwe, Wohlfart, Paulus, Schäfer, Matthias, Bielohuby, Maximilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890245/
https://www.ncbi.nlm.nih.gov/pubmed/31794591
http://dx.doi.org/10.1371/journal.pone.0225835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890245/
https://www.ncbi.nlm.nih.gov/pubmed/31794591
http://dx.doi.org/10.1371/journal.pone.0225835

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