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The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy: A systematic review and a meta-analysis

BACKGROUND: Vitamin D is a fat-soluble vitamin that is related to the health of the human body and is an indispensable nutrient for human beings. Some studies indicated that type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN) may be associated with vitamin D deficiency, but the...

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Autores principales: Zhang, Binjie, Zhao, Wenli, Tu, Jinli, Wang, Xueying, Hao, Yu, Wang, Hongwu, Zhao, Ye, Mizuno, Kaito, Tseng, Yiider, Bu, Huaien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890351/
https://www.ncbi.nlm.nih.gov/pubmed/31770239
http://dx.doi.org/10.1097/MD.0000000000018118
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author Zhang, Binjie
Zhao, Wenli
Tu, Jinli
Wang, Xueying
Hao, Yu
Wang, Hongwu
Zhao, Ye
Mizuno, Kaito
Tseng, Yiider
Bu, Huaien
author_facet Zhang, Binjie
Zhao, Wenli
Tu, Jinli
Wang, Xueying
Hao, Yu
Wang, Hongwu
Zhao, Ye
Mizuno, Kaito
Tseng, Yiider
Bu, Huaien
author_sort Zhang, Binjie
collection PubMed
description BACKGROUND: Vitamin D is a fat-soluble vitamin that is related to the health of the human body and is an indispensable nutrient for human beings. Some studies indicated that type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN) may be associated with vitamin D deficiency, but the current understanding of this point of view remains controversial. This study aimed to evaluate the correlation between serum 25-hydroxyl vitamin D (25 [OH] D) concentration and DPN in patients with T2DM by a meta-analysis, and to provide a reference for doctors. METHODS: Relevant studies were selected from the PubMed, Cochrane Library, China National Knowledge Infrastructure, VIP databases, and Wanfang Data Knowledge Service Platform databases dating from 2000 to December 2017. A total of 75 articles related to serum 25 (OH) D and DPN were selected from 2000 to December 2017. Based on the inclusion and exclusion criteria of the literature, a quality assessment was conducted using the Newcastle–Ottawa scale, and a meta-analysis was performed by RevMan5.3 statistical software. RESULTS: Thirteen studies that involved a total of 2814 type 2 diabetic patients were finally included into the meta-analysis. Meta-analysis results, heterogeneity test showed that, P < .000 01, I(2) = 92%, calculation by random effect model revealed that, the serum concentration of 25 (OH) D in T2DM combined with DPN group was lower than that in the group without DPN (weighted mean difference = −0.74, 95% confidence interval: −1.03 to −0.46) CONCLUSIONS: Vitamin D is associated with type 2 DPN (DPN), and vitamin D deficiency can lead to an increased risk of type 2 DPN. However, more high-quality research is needed.
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spelling pubmed-68903512020-01-22 The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy: A systematic review and a meta-analysis Zhang, Binjie Zhao, Wenli Tu, Jinli Wang, Xueying Hao, Yu Wang, Hongwu Zhao, Ye Mizuno, Kaito Tseng, Yiider Bu, Huaien Medicine (Baltimore) 5300 BACKGROUND: Vitamin D is a fat-soluble vitamin that is related to the health of the human body and is an indispensable nutrient for human beings. Some studies indicated that type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN) may be associated with vitamin D deficiency, but the current understanding of this point of view remains controversial. This study aimed to evaluate the correlation between serum 25-hydroxyl vitamin D (25 [OH] D) concentration and DPN in patients with T2DM by a meta-analysis, and to provide a reference for doctors. METHODS: Relevant studies were selected from the PubMed, Cochrane Library, China National Knowledge Infrastructure, VIP databases, and Wanfang Data Knowledge Service Platform databases dating from 2000 to December 2017. A total of 75 articles related to serum 25 (OH) D and DPN were selected from 2000 to December 2017. Based on the inclusion and exclusion criteria of the literature, a quality assessment was conducted using the Newcastle–Ottawa scale, and a meta-analysis was performed by RevMan5.3 statistical software. RESULTS: Thirteen studies that involved a total of 2814 type 2 diabetic patients were finally included into the meta-analysis. Meta-analysis results, heterogeneity test showed that, P < .000 01, I(2) = 92%, calculation by random effect model revealed that, the serum concentration of 25 (OH) D in T2DM combined with DPN group was lower than that in the group without DPN (weighted mean difference = −0.74, 95% confidence interval: −1.03 to −0.46) CONCLUSIONS: Vitamin D is associated with type 2 DPN (DPN), and vitamin D deficiency can lead to an increased risk of type 2 DPN. However, more high-quality research is needed. Wolters Kluwer Health 2019-11-27 /pmc/articles/PMC6890351/ /pubmed/31770239 http://dx.doi.org/10.1097/MD.0000000000018118 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5300
Zhang, Binjie
Zhao, Wenli
Tu, Jinli
Wang, Xueying
Hao, Yu
Wang, Hongwu
Zhao, Ye
Mizuno, Kaito
Tseng, Yiider
Bu, Huaien
The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy: A systematic review and a meta-analysis
title The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy: A systematic review and a meta-analysis
title_full The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy: A systematic review and a meta-analysis
title_fullStr The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy: A systematic review and a meta-analysis
title_full_unstemmed The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy: A systematic review and a meta-analysis
title_short The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy: A systematic review and a meta-analysis
title_sort relationship between serum 25-hydroxyvitamin d concentration and type 2 diabetic peripheral neuropathy: a systematic review and a meta-analysis
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890351/
https://www.ncbi.nlm.nih.gov/pubmed/31770239
http://dx.doi.org/10.1097/MD.0000000000018118
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