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Upregulated expression of G9a is correlated with poor prognosis of gastric cancer patients

As one of the most serious cancers, gastric cancer (GC) represents the third leading cause of malignancy-related deaths. G9a is a histone lysine methyltransferase and has been reported to be involved in the progression of some human cancers. In the present study, we aimed to explore the expression p...

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Autores principales: Zhang, Chi, Wei, Shaozhong, Hu, Junjie, Xiong, Zhiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890365/
https://www.ncbi.nlm.nih.gov/pubmed/31770281
http://dx.doi.org/10.1097/MD.0000000000018212
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author Zhang, Chi
Wei, Shaozhong
Hu, Junjie
Xiong, Zhiguo
author_facet Zhang, Chi
Wei, Shaozhong
Hu, Junjie
Xiong, Zhiguo
author_sort Zhang, Chi
collection PubMed
description As one of the most serious cancers, gastric cancer (GC) represents the third leading cause of malignancy-related deaths. G9a is a histone lysine methyltransferase and has been reported to be involved in the progression of some human cancers. In the present study, we aimed to explore the expression patterns and clinical value of G9a in GC patients. The expression of G9a in 142 paired GC tissues and adjacent non-cancerous tissues (no less than 5 cm from tumor edge) was examined with quantitative real-time polymerase chain reaction (qRT-PCR). To estimate the association of G9a expression with clinical characteristics of GC patients, Chi-square test and t test were conducted. Kaplan–Meier survival and multivariate Cox regression analyses were performed to explore the prognostic value of G9a in GC. Upregulated expression of G9a was found in GC tissues compared with noncancerous tissues (P < .001). Elevated G9a expression was significantly correlated with patients’ lymph node metastasis (P = .007) and TNM stage (P < .001). Kaplan–Meier survival curves demonstrated that patients with high G9a expression had shorter survival time than those with low expression (log-rank test, P < .05), reaching a median OS of 24 months. According to the results of Cox regression, G9a could be considered as an independent prognostic biomarker in patients with GC (HR = 3.912, 95% CI = 2.213–6.915, P < .001). Additionally, the diagnosis cut-off value of G9a in GC patients was 1.515. Taken together, G9a expression was upregulated in GC tissues and could be an effective prognostic biomarker for GC.
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spelling pubmed-68903652020-01-22 Upregulated expression of G9a is correlated with poor prognosis of gastric cancer patients Zhang, Chi Wei, Shaozhong Hu, Junjie Xiong, Zhiguo Medicine (Baltimore) 5700 As one of the most serious cancers, gastric cancer (GC) represents the third leading cause of malignancy-related deaths. G9a is a histone lysine methyltransferase and has been reported to be involved in the progression of some human cancers. In the present study, we aimed to explore the expression patterns and clinical value of G9a in GC patients. The expression of G9a in 142 paired GC tissues and adjacent non-cancerous tissues (no less than 5 cm from tumor edge) was examined with quantitative real-time polymerase chain reaction (qRT-PCR). To estimate the association of G9a expression with clinical characteristics of GC patients, Chi-square test and t test were conducted. Kaplan–Meier survival and multivariate Cox regression analyses were performed to explore the prognostic value of G9a in GC. Upregulated expression of G9a was found in GC tissues compared with noncancerous tissues (P < .001). Elevated G9a expression was significantly correlated with patients’ lymph node metastasis (P = .007) and TNM stage (P < .001). Kaplan–Meier survival curves demonstrated that patients with high G9a expression had shorter survival time than those with low expression (log-rank test, P < .05), reaching a median OS of 24 months. According to the results of Cox regression, G9a could be considered as an independent prognostic biomarker in patients with GC (HR = 3.912, 95% CI = 2.213–6.915, P < .001). Additionally, the diagnosis cut-off value of G9a in GC patients was 1.515. Taken together, G9a expression was upregulated in GC tissues and could be an effective prognostic biomarker for GC. Wolters Kluwer Health 2019-11-27 /pmc/articles/PMC6890365/ /pubmed/31770281 http://dx.doi.org/10.1097/MD.0000000000018212 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5700
Zhang, Chi
Wei, Shaozhong
Hu, Junjie
Xiong, Zhiguo
Upregulated expression of G9a is correlated with poor prognosis of gastric cancer patients
title Upregulated expression of G9a is correlated with poor prognosis of gastric cancer patients
title_full Upregulated expression of G9a is correlated with poor prognosis of gastric cancer patients
title_fullStr Upregulated expression of G9a is correlated with poor prognosis of gastric cancer patients
title_full_unstemmed Upregulated expression of G9a is correlated with poor prognosis of gastric cancer patients
title_short Upregulated expression of G9a is correlated with poor prognosis of gastric cancer patients
title_sort upregulated expression of g9a is correlated with poor prognosis of gastric cancer patients
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890365/
https://www.ncbi.nlm.nih.gov/pubmed/31770281
http://dx.doi.org/10.1097/MD.0000000000018212
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