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Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor κB pathways

The ubiquitin proteasome pathway is essential for the proliferation and survival of multiple myeloma (MM) cells. TAS4464, a novel highly potent inhibitor of NEDD8 activating enzyme, selectively inactivates cullin‐RING ubiquitin E3 ligases, resulting in accumulation of their substrates. Here, we exam...

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Detalles Bibliográficos
Autores principales:	Muraoka, Hiromi, Yoshimura, Chihoko, Kawabata, Rumi, Tsuji, Shingo, Hashimoto, Akihiro, Ochiiwa, Hiroaki, Nakagawa, Fumio, Fujioka, Yayoi, Matsuo, Kenichi, Ohkubo, Shuichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890451/ https://www.ncbi.nlm.nih.gov/pubmed/31583781 http://dx.doi.org/10.1111/cas.14209

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