RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Long-distance RNA transport enables local protein synthesis at metabolically-active sites distant from the nucleus. This process ensures an appropriate spatial organization of proteins, vital to polarized cells such as neurons. Here, we present a mechanism for RNA transport in which RNA granules “hi...

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Detalles Bibliográficos
Autores principales: Liao, Ya-Cheng, Fernandopulle, Michael S., Wang, Guozhen, Choi, Heejun, Hao, Ling, Drerup, Catherine M., Patel, Rajan, Qamar, Seema, Nixon-Abell, Jonathon, Shen, Yi, Meadows, William, Vendruscolo, Michele, Knowles, Tuomas P.J., Nelson, Matthew, Czekalska, Magdalena A., Musteikyte, Greta, Gachechiladze, Mariam A., Stephens, Christina A., Pasolli, H. Amalia, Forrest, Lucy R., St George-Hyslop, Peter, Lippincott-Schwartz, Jennifer, Ward, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890474/
https://www.ncbi.nlm.nih.gov/pubmed/31539493
http://dx.doi.org/10.1016/j.cell.2019.08.050

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