Repression of phagocytosis by human CD33 is not conserved with mouse CD33

CD33 is an immunomodulatory receptor linked to Alzheimer’s disease (AD) susceptibility via regulation of phagocytosis in microglia. Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33. The functional c...

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Detalles Bibliográficos
Autores principales: Bhattacherjee, Abhishek, Rodrigues, Emily, Jung, Jaesoo, Luzentales-Simpson, Matthew, Enterina, Jhon R., Galleguillos, Danny, St. Laurent, Chris D., Nakhaei-Nejad, Maryam, Fuchsberger, Felix F., Streith, Laura, Wang, Qian, Kawasaki, Norihito, Duan, Shiteng, Bains, Arjun, Paulson, James C., Rademacher, Christoph, Giuliani, Fabrizio, Sipione, Simonetta, Macauley, Matthew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890642/
https://www.ncbi.nlm.nih.gov/pubmed/31815204
http://dx.doi.org/10.1038/s42003-019-0698-6

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