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Immunological effects of shift work in healthcare workers

The immune system potentially plays an important mechanistic role in the relation between shift work and adverse health effects. To better understand the immunological effects of shift work, we compared numbers and functionality of immune cells between night-shift and non-shift workers. Blood sample...

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Autores principales: Loef, Bette, Nanlohy, Nening M., Jacobi, Ronald H. J., van de Ven, Chantal, Mariman, Rob, van der Beek, Allard J., Proper, Karin I., van Baarle, Debbie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890754/
https://www.ncbi.nlm.nih.gov/pubmed/31796836
http://dx.doi.org/10.1038/s41598-019-54816-5
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author Loef, Bette
Nanlohy, Nening M.
Jacobi, Ronald H. J.
van de Ven, Chantal
Mariman, Rob
van der Beek, Allard J.
Proper, Karin I.
van Baarle, Debbie
author_facet Loef, Bette
Nanlohy, Nening M.
Jacobi, Ronald H. J.
van de Ven, Chantal
Mariman, Rob
van der Beek, Allard J.
Proper, Karin I.
van Baarle, Debbie
author_sort Loef, Bette
collection PubMed
description The immune system potentially plays an important mechanistic role in the relation between shift work and adverse health effects. To better understand the immunological effects of shift work, we compared numbers and functionality of immune cells between night-shift and non-shift workers. Blood samples were collected from 254 night-shift and 57 non-shift workers employed in hospitals. Absolute numbers of monocytes, granulocytes, lymphocytes, and T cell subsets were assessed. As read out of immune function, monocyte cytokine production and proliferative capacity of CD4 and CD8 T cells in response to various stimuli were analysed. The mean number of monocytes was 1.15 (95%-CI = 1.05–1.26) times higher in night-shift than in non-shift workers. Furthermore, night-shift workers who worked night shifts in the past three days had a higher mean number of lymphocytes (B = 1.12 (95%-CI = 1.01–1.26)), T cells (B = 1.16 (95%-CI = 1.03–1.31)), and CD8 T cells (B = 1.23 (95%-CI = 1.05–1.45)) compared to non-shift workers. No differences in functional parameters of monocytes and lymphocytes were observed. The differences in numbers of monocytes and T cells suggest that chronic exposure to night-shift work as well as recent night-shift work may influence the immune status of healthcare workers. This knowledge could be relevant for preventive initiatives in night-shift workers, such as timing of vaccination.
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spelling pubmed-68907542019-12-10 Immunological effects of shift work in healthcare workers Loef, Bette Nanlohy, Nening M. Jacobi, Ronald H. J. van de Ven, Chantal Mariman, Rob van der Beek, Allard J. Proper, Karin I. van Baarle, Debbie Sci Rep Article The immune system potentially plays an important mechanistic role in the relation between shift work and adverse health effects. To better understand the immunological effects of shift work, we compared numbers and functionality of immune cells between night-shift and non-shift workers. Blood samples were collected from 254 night-shift and 57 non-shift workers employed in hospitals. Absolute numbers of monocytes, granulocytes, lymphocytes, and T cell subsets were assessed. As read out of immune function, monocyte cytokine production and proliferative capacity of CD4 and CD8 T cells in response to various stimuli were analysed. The mean number of monocytes was 1.15 (95%-CI = 1.05–1.26) times higher in night-shift than in non-shift workers. Furthermore, night-shift workers who worked night shifts in the past three days had a higher mean number of lymphocytes (B = 1.12 (95%-CI = 1.01–1.26)), T cells (B = 1.16 (95%-CI = 1.03–1.31)), and CD8 T cells (B = 1.23 (95%-CI = 1.05–1.45)) compared to non-shift workers. No differences in functional parameters of monocytes and lymphocytes were observed. The differences in numbers of monocytes and T cells suggest that chronic exposure to night-shift work as well as recent night-shift work may influence the immune status of healthcare workers. This knowledge could be relevant for preventive initiatives in night-shift workers, such as timing of vaccination. Nature Publishing Group UK 2019-12-03 /pmc/articles/PMC6890754/ /pubmed/31796836 http://dx.doi.org/10.1038/s41598-019-54816-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Loef, Bette
Nanlohy, Nening M.
Jacobi, Ronald H. J.
van de Ven, Chantal
Mariman, Rob
van der Beek, Allard J.
Proper, Karin I.
van Baarle, Debbie
Immunological effects of shift work in healthcare workers
title Immunological effects of shift work in healthcare workers
title_full Immunological effects of shift work in healthcare workers
title_fullStr Immunological effects of shift work in healthcare workers
title_full_unstemmed Immunological effects of shift work in healthcare workers
title_short Immunological effects of shift work in healthcare workers
title_sort immunological effects of shift work in healthcare workers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890754/
https://www.ncbi.nlm.nih.gov/pubmed/31796836
http://dx.doi.org/10.1038/s41598-019-54816-5
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