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p38α Mitogen-Activated Protein Kinase Is a Druggable Target in Pancreatic Adenocarcinoma

p38 mitogen-activated protein kinases are signaling molecules with major involvement in cancer. A detailed mechanistic understanding of how p38 MAPK family members function is urgently warranted for cancer targeted therapy. The conformational dynamics of the most common member of p38 MAPK family, p3...

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Detalles Bibliográficos
Autores principales: Yang, Ling, Sun, Xiaoting, Ye, Ying, Lu, Yongtian, Zuo, Ji, Liu, Wen, Elcock, Adrian, Zhu, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890821/
https://www.ncbi.nlm.nih.gov/pubmed/31828036
http://dx.doi.org/10.3389/fonc.2019.01294