Cargando…

Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality amongst civilians and military personnel globally. Despite advances in our knowledge of the complex pathophysiology of TBI, the underlying mechanisms are yet to be fully elucidated. While initial brain insult i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ng, Si Yun, Lee, Alan Yiu Wah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890857/ https://www.ncbi.nlm.nih.gov/pubmed/31827423 http://dx.doi.org/10.3389/fncel.2019.00528

Ejemplares similares

Brain-Derived Neurotrophic Factor Is an Important Therapeutic Factor in Mesenchymal Stem Cell Secretions for Treatment of Traumatic Peripheral Pelvic Injuries
por: Yuan, Xiaoyi, et al.
Publicado: (2022)

Editorial: Perinatal hypoxic-ischemic brain injury: Mechanisms, pathogenesis, and potential therapeutic strategies
por: Chen, Xiaodi, et al.
Publicado: (2022)

Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury
por: Shi, Mingming, et al.
Publicado: (2021)

Editorial: Non-coding RNAs in diseases of the nervous system
por: Reschke, Cristina R., et al.
Publicado: (2023)

Traumatic Brain Injury Alters Methionine Metabolism: Implications for Pathophysiology
por: Dash, Pramod K., et al.
Publicado: (2016)

Applying hiPSCs and Biomaterials Towards an Understanding and Treatment of Traumatic Brain Injury
por: Lacalle-Aurioles, María, et al.
Publicado: (2020)

Mild Traumatic Brain Injury-Induced Disruption of the Blood-Brain Barrier Triggers an Atypical Neuronal Response
por: Munoz-Ballester, Carmen, et al.
Publicado: (2022)

Ablation of GSDMD Attenuates Neurological Deficits and Neuropathological Alterations After Traumatic Brain Injury
por: Du, Hao, et al.
Publicado: (2022)

The Role of Substance P in Secondary Pathophysiology after Traumatic Brain Injury
por: Vink, Robert, et al.
Publicado: (2017)

Inhibition of Exosome Release Alleviates Cognitive Impairment After Repetitive Mild Traumatic Brain Injury
por: Hu, Tianpeng, et al.
Publicado: (2022)

Upregulation of LRRK2 following traumatic brain injury does not directly phosphorylate Thr(175) tau
por: Donison, Neil, et al.
Publicado: (2023)

Editorial: Therapeutic relevance and mechanisms of neuro-immune communication in brain injury
por: Zhang, Pengyue, et al.
Publicado: (2023)

Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention
por: Zhang, Li, et al.
Publicado: (2018)

Contributions of the immune system to the pathophysiology of traumatic brain injury – evidence by intravital microscopy
por: Schwarzmaier, Susanne M., et al.
Publicado: (2014)

Editorial: Microglia as a Therapeutic Target for Brain Repair: Opportunities and Challenges
por: Zhou, Kai, et al.
Publicado: (2022)

Strategies for Oligodendrocyte and Myelin Repair in Traumatic CNS Injury
por: Huntemer-Silveira, Anne, et al.
Publicado: (2021)

Neuroinflammation aggravated by traumatic brain injury at high altitude is reversed by L-serine via NFAT1-mediated microglial polarization
por: Liu, Jinchun, et al.
Publicado: (2023)

Therapeutic Hypothermia in Stroke and Traumatic Brain Injury
por: Faridar, Alireza, et al.
Publicado: (2011)

Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke
por: Fu, Jiaqi, et al.
Publicado: (2023)

The role and potential therapeutic targets of astrocytes in central nervous system demyelinating diseases
por: Tan, Rui, et al.
Publicado: (2023)

P2RX7 in Dopaminergic Neurons of Ventral Periaqueductal Gray Mediates HTWP Acupuncture-Induced Consciousness in Traumatic Brain Injury
por: Tang, Huiling, et al.
Publicado: (2021)

Protein Expression of the Microglial Marker Tmem119 Decreases in Association With Morphological Changes and Location in a Mouse Model of Traumatic Brain Injury
por: Mercurio, Domenico, et al.
Publicado: (2022)

HIF-1α Mediates TRAIL-Induced Neuronal Apoptosis via Regulating DcR1 Expression Following Traumatic Brain Injury
por: Fang, Yuanjian, et al.
Publicado: (2020)

Editorial: Modulation of neuronal excitability by non-neuronal cells in physiological and pathophysiological conditions
por: Chen, Rongqing, et al.
Publicado: (2023)

Involvement of Mast Cells in the Pathophysiology of Pain
por: Mai, Lijia, et al.
Publicado: (2021)

The Functional Role of Spinal Interneurons Following Traumatic Spinal Cord Injury
por: Zavvarian, Mohammad-Masoud, et al.
Publicado: (2020)

Editorial: Experimental and Clinical Approaches in the Pursuit of Novel Therapeutic Strategies for Perinatal Brain Injury and Its Neurological Sequelae
por: Zhu, Changlian, et al.
Publicado: (2021)

WDR43 is a potential diagnostic biomarker and therapeutic target for osteoarthritis complicated with Parkinson’s disease
por: Heng, Hongquan, et al.
Publicado: (2022)

Cellular Physiology and Pathophysiology of EAAT Anion Channels
por: Kovermann, Peter, et al.
Publicado: (2022)

Megalencephalic Leukoencephalopathy: Insights Into Pathophysiology and Perspectives for Therapy
por: Bosch, Assumpció, et al.
Publicado: (2021)

Forgotten Fibrocytes: A Neglected, Supporting Cell Type of the Cochlea With the Potential to be an Alternative Therapeutic Target in Hearing Loss
por: Furness, David N.
Publicado: (2019)

A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases
por: Saha, Sarmistha, et al.
Publicado: (2022)

The Importance of Therapeutic Time Window in the Treatment of Traumatic Brain Injury
por: Mohamadpour, Maliheh, et al.
Publicado: (2019)

Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications
por: Sipione, Simonetta, et al.
Publicado: (2020)

Pathophysiology of Pediatric Traumatic Brain Injury
por: Serpa, Rebecka O., et al.
Publicado: (2021)

Persistent Neurovascular Unit Dysfunction: Pathophysiological Substrate and Trigger for Late-Onset Neurodegeneration After Traumatic Brain Injury
por: Zhou, Yunxiang, et al.
Publicado: (2020)

NLRP3 Inflammasome: A Potential Target in Isoflurane Pretreatment Alleviates Stroke-Induced Retinal Injury in Diabetes
por: Lin, Hong-Bin, et al.
Publicado: (2021)

Editorial: Role of metal ions in central nervous system: Physiology and pathophysiology
por: Guo, Feng, et al.
Publicado: (2022)

Editorial: Neural pathophysiological mechanisms of neuropsychiatric disorders underlying substance abuse
por: Wang, Zhuo, et al.
Publicado: (2023)

Lymphocytes Contribute to the Pathophysiology of Neonatal Brain Injury
por: Nazmi, Arshed, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vbnhjlmsj1053ipjmj8a6rqa5h