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Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept

Pharmacokinetic modelling on dynamic positron emission tomography (PET) data is a quantitative technique. However, the long acquisition time is prohibitive for routine clinical use. Instead, the semi-quantitative standardised uptake value ratio (SUVR) from a shorter static acquisition is used, despi...

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Autores principales: Scott, Catherine J, Jiao, Jieqing, Melbourne, Andrew, Burgos, Ninon, Cash, David M, De Vita, Enrico, Markiewicz, Pawel J, O'Connor, Antoinette, Thomas, David L, Weston, Philip SJ, Schott, Jonathan M, Hutton, Brian F, Ourselin, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891000/
https://www.ncbi.nlm.nih.gov/pubmed/30182792
http://dx.doi.org/10.1177/0271678X18797343
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author Scott, Catherine J
Jiao, Jieqing
Melbourne, Andrew
Burgos, Ninon
Cash, David M
De Vita, Enrico
Markiewicz, Pawel J
O'Connor, Antoinette
Thomas, David L
Weston, Philip SJ
Schott, Jonathan M
Hutton, Brian F
Ourselin, Sébastien
author_facet Scott, Catherine J
Jiao, Jieqing
Melbourne, Andrew
Burgos, Ninon
Cash, David M
De Vita, Enrico
Markiewicz, Pawel J
O'Connor, Antoinette
Thomas, David L
Weston, Philip SJ
Schott, Jonathan M
Hutton, Brian F
Ourselin, Sébastien
author_sort Scott, Catherine J
collection PubMed
description Pharmacokinetic modelling on dynamic positron emission tomography (PET) data is a quantitative technique. However, the long acquisition time is prohibitive for routine clinical use. Instead, the semi-quantitative standardised uptake value ratio (SUVR) from a shorter static acquisition is used, despite its sensitivity to blood flow confounding longitudinal analysis. A method has been proposed to reduce the dynamic acquisition time for quantification by incorporating cerebral blood flow (CBF) information from arterial spin labelling (ASL) magnetic resonance imaging (MRI) into the pharmacokinetic modelling. In this work, we optimise and validate this framework for a study of ageing and preclinical Alzheimer's disease. This methodology adapts the simplified reference tissue model (SRTM) for a reduced acquisition time (RT-SRTM) and is applied to [(18)F]-florbetapir PET data for amyloid-β quantification. Evaluation shows that the optimised RT-SRTM can achieve amyloid burden estimation from a 30-min PET/MR acquisition which is comparable with the gold standard SRTM applied to 60 min of PET data. Conversely, SUVR showed a significantly higher error and bias, and a statistically significant correlation with tracer delivery due to the influence of blood flow. The optimised RT-SRTM produced amyloid burden estimates which were uncorrelated with tracer delivery indicating its suitability for longitudinal studies.
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spelling pubmed-68910002019-12-12 Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept Scott, Catherine J Jiao, Jieqing Melbourne, Andrew Burgos, Ninon Cash, David M De Vita, Enrico Markiewicz, Pawel J O'Connor, Antoinette Thomas, David L Weston, Philip SJ Schott, Jonathan M Hutton, Brian F Ourselin, Sébastien J Cereb Blood Flow Metab Original Articles Pharmacokinetic modelling on dynamic positron emission tomography (PET) data is a quantitative technique. However, the long acquisition time is prohibitive for routine clinical use. Instead, the semi-quantitative standardised uptake value ratio (SUVR) from a shorter static acquisition is used, despite its sensitivity to blood flow confounding longitudinal analysis. A method has been proposed to reduce the dynamic acquisition time for quantification by incorporating cerebral blood flow (CBF) information from arterial spin labelling (ASL) magnetic resonance imaging (MRI) into the pharmacokinetic modelling. In this work, we optimise and validate this framework for a study of ageing and preclinical Alzheimer's disease. This methodology adapts the simplified reference tissue model (SRTM) for a reduced acquisition time (RT-SRTM) and is applied to [(18)F]-florbetapir PET data for amyloid-β quantification. Evaluation shows that the optimised RT-SRTM can achieve amyloid burden estimation from a 30-min PET/MR acquisition which is comparable with the gold standard SRTM applied to 60 min of PET data. Conversely, SUVR showed a significantly higher error and bias, and a statistically significant correlation with tracer delivery due to the influence of blood flow. The optimised RT-SRTM produced amyloid burden estimates which were uncorrelated with tracer delivery indicating its suitability for longitudinal studies. SAGE Publications 2018-09-05 2019-12 /pmc/articles/PMC6891000/ /pubmed/30182792 http://dx.doi.org/10.1177/0271678X18797343 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Scott, Catherine J
Jiao, Jieqing
Melbourne, Andrew
Burgos, Ninon
Cash, David M
De Vita, Enrico
Markiewicz, Pawel J
O'Connor, Antoinette
Thomas, David L
Weston, Philip SJ
Schott, Jonathan M
Hutton, Brian F
Ourselin, Sébastien
Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept
title Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept
title_full Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept
title_fullStr Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept
title_full_unstemmed Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept
title_short Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept
title_sort reduced acquisition time pet pharmacokinetic modelling using simultaneous asl–mri: proof of concept
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891000/
https://www.ncbi.nlm.nih.gov/pubmed/30182792
http://dx.doi.org/10.1177/0271678X18797343
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