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Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept
Pharmacokinetic modelling on dynamic positron emission tomography (PET) data is a quantitative technique. However, the long acquisition time is prohibitive for routine clinical use. Instead, the semi-quantitative standardised uptake value ratio (SUVR) from a shorter static acquisition is used, despi...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891000/ https://www.ncbi.nlm.nih.gov/pubmed/30182792 http://dx.doi.org/10.1177/0271678X18797343 |
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author | Scott, Catherine J Jiao, Jieqing Melbourne, Andrew Burgos, Ninon Cash, David M De Vita, Enrico Markiewicz, Pawel J O'Connor, Antoinette Thomas, David L Weston, Philip SJ Schott, Jonathan M Hutton, Brian F Ourselin, Sébastien |
author_facet | Scott, Catherine J Jiao, Jieqing Melbourne, Andrew Burgos, Ninon Cash, David M De Vita, Enrico Markiewicz, Pawel J O'Connor, Antoinette Thomas, David L Weston, Philip SJ Schott, Jonathan M Hutton, Brian F Ourselin, Sébastien |
author_sort | Scott, Catherine J |
collection | PubMed |
description | Pharmacokinetic modelling on dynamic positron emission tomography (PET) data is a quantitative technique. However, the long acquisition time is prohibitive for routine clinical use. Instead, the semi-quantitative standardised uptake value ratio (SUVR) from a shorter static acquisition is used, despite its sensitivity to blood flow confounding longitudinal analysis. A method has been proposed to reduce the dynamic acquisition time for quantification by incorporating cerebral blood flow (CBF) information from arterial spin labelling (ASL) magnetic resonance imaging (MRI) into the pharmacokinetic modelling. In this work, we optimise and validate this framework for a study of ageing and preclinical Alzheimer's disease. This methodology adapts the simplified reference tissue model (SRTM) for a reduced acquisition time (RT-SRTM) and is applied to [(18)F]-florbetapir PET data for amyloid-β quantification. Evaluation shows that the optimised RT-SRTM can achieve amyloid burden estimation from a 30-min PET/MR acquisition which is comparable with the gold standard SRTM applied to 60 min of PET data. Conversely, SUVR showed a significantly higher error and bias, and a statistically significant correlation with tracer delivery due to the influence of blood flow. The optimised RT-SRTM produced amyloid burden estimates which were uncorrelated with tracer delivery indicating its suitability for longitudinal studies. |
format | Online Article Text |
id | pubmed-6891000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-68910002019-12-12 Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept Scott, Catherine J Jiao, Jieqing Melbourne, Andrew Burgos, Ninon Cash, David M De Vita, Enrico Markiewicz, Pawel J O'Connor, Antoinette Thomas, David L Weston, Philip SJ Schott, Jonathan M Hutton, Brian F Ourselin, Sébastien J Cereb Blood Flow Metab Original Articles Pharmacokinetic modelling on dynamic positron emission tomography (PET) data is a quantitative technique. However, the long acquisition time is prohibitive for routine clinical use. Instead, the semi-quantitative standardised uptake value ratio (SUVR) from a shorter static acquisition is used, despite its sensitivity to blood flow confounding longitudinal analysis. A method has been proposed to reduce the dynamic acquisition time for quantification by incorporating cerebral blood flow (CBF) information from arterial spin labelling (ASL) magnetic resonance imaging (MRI) into the pharmacokinetic modelling. In this work, we optimise and validate this framework for a study of ageing and preclinical Alzheimer's disease. This methodology adapts the simplified reference tissue model (SRTM) for a reduced acquisition time (RT-SRTM) and is applied to [(18)F]-florbetapir PET data for amyloid-β quantification. Evaluation shows that the optimised RT-SRTM can achieve amyloid burden estimation from a 30-min PET/MR acquisition which is comparable with the gold standard SRTM applied to 60 min of PET data. Conversely, SUVR showed a significantly higher error and bias, and a statistically significant correlation with tracer delivery due to the influence of blood flow. The optimised RT-SRTM produced amyloid burden estimates which were uncorrelated with tracer delivery indicating its suitability for longitudinal studies. SAGE Publications 2018-09-05 2019-12 /pmc/articles/PMC6891000/ /pubmed/30182792 http://dx.doi.org/10.1177/0271678X18797343 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Scott, Catherine J Jiao, Jieqing Melbourne, Andrew Burgos, Ninon Cash, David M De Vita, Enrico Markiewicz, Pawel J O'Connor, Antoinette Thomas, David L Weston, Philip SJ Schott, Jonathan M Hutton, Brian F Ourselin, Sébastien Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept |
title | Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept |
title_full | Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept |
title_fullStr | Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept |
title_full_unstemmed | Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept |
title_short | Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL–MRI: proof of concept |
title_sort | reduced acquisition time pet pharmacokinetic modelling using simultaneous asl–mri: proof of concept |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891000/ https://www.ncbi.nlm.nih.gov/pubmed/30182792 http://dx.doi.org/10.1177/0271678X18797343 |
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