Cargando…

Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models

The present work was carried out to assess the Onosma bracteatum anxiolytic and antidepressant properties. Swiss albino mice (male) were fed orally with hydroalcoholic extract at different doses 50, 100, and 200 mg 1 hour prior to test with the standard diazepam and fluoxetine. Anxiolytic and antide...

Descripción completa

Detalles Bibliográficos
Autores principales: Asif, Hafiz Muhammad, Hayee, Abdul, Aslam, Muhammad Rahil, Ahmad, Khalil, Hashmi, Abdul Sattar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891010/
https://www.ncbi.nlm.nih.gov/pubmed/31832027
http://dx.doi.org/10.1177/1559325819891262
_version_ 1783475738584809472
author Asif, Hafiz Muhammad
Hayee, Abdul
Aslam, Muhammad Rahil
Ahmad, Khalil
Hashmi, Abdul Sattar
author_facet Asif, Hafiz Muhammad
Hayee, Abdul
Aslam, Muhammad Rahil
Ahmad, Khalil
Hashmi, Abdul Sattar
author_sort Asif, Hafiz Muhammad
collection PubMed
description The present work was carried out to assess the Onosma bracteatum anxiolytic and antidepressant properties. Swiss albino mice (male) were fed orally with hydroalcoholic extract at different doses 50, 100, and 200 mg 1 hour prior to test with the standard diazepam and fluoxetine. Anxiolytic and antidepressant activities were evaluated by using open field, elevated plus maze, force swimming, and tail suspension test. Results of open field test showed an increase in number of line crossing as well as number of rearing in dosage-dependent design. Although results of elevated plus maze test evidently showed antianxiety effect of O bracteatum by increasing the time spent in open arms along with decreasing the time spent in closed arms in dosage-dependent way. For the evaluation of antidepressant effect, O bracteatum diminished the immobility time and expanded mobility time in forced swim model in dosage-dependent way. Likewise, O bracteatum expanded time span of mobility along with diminished immobility time in tail suspension method in dosage-dependent way. Outcome demonstrated that plant at the dose of 200 mg/kg body weight showed significant potential which was similar to that standard diazepam and fluoxetine. Hence, O bracteatum may be used as potent natural psychotherapeutic agent against the mental disorders.
format Online
Article
Text
id pubmed-6891010
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-68910102019-12-12 Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models Asif, Hafiz Muhammad Hayee, Abdul Aslam, Muhammad Rahil Ahmad, Khalil Hashmi, Abdul Sattar Dose Response Original Article The present work was carried out to assess the Onosma bracteatum anxiolytic and antidepressant properties. Swiss albino mice (male) were fed orally with hydroalcoholic extract at different doses 50, 100, and 200 mg 1 hour prior to test with the standard diazepam and fluoxetine. Anxiolytic and antidepressant activities were evaluated by using open field, elevated plus maze, force swimming, and tail suspension test. Results of open field test showed an increase in number of line crossing as well as number of rearing in dosage-dependent design. Although results of elevated plus maze test evidently showed antianxiety effect of O bracteatum by increasing the time spent in open arms along with decreasing the time spent in closed arms in dosage-dependent way. For the evaluation of antidepressant effect, O bracteatum diminished the immobility time and expanded mobility time in forced swim model in dosage-dependent way. Likewise, O bracteatum expanded time span of mobility along with diminished immobility time in tail suspension method in dosage-dependent way. Outcome demonstrated that plant at the dose of 200 mg/kg body weight showed significant potential which was similar to that standard diazepam and fluoxetine. Hence, O bracteatum may be used as potent natural psychotherapeutic agent against the mental disorders. SAGE Publications 2019-12-03 /pmc/articles/PMC6891010/ /pubmed/31832027 http://dx.doi.org/10.1177/1559325819891262 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Asif, Hafiz Muhammad
Hayee, Abdul
Aslam, Muhammad Rahil
Ahmad, Khalil
Hashmi, Abdul Sattar
Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models
title Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models
title_full Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models
title_fullStr Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models
title_full_unstemmed Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models
title_short Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models
title_sort dose-dependent, antidepressant, and anxiolytic effects of a traditional medicinal plant for the management of behavioral dysfunctions in animal models
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891010/
https://www.ncbi.nlm.nih.gov/pubmed/31832027
http://dx.doi.org/10.1177/1559325819891262
work_keys_str_mv AT asifhafizmuhammad dosedependentantidepressantandanxiolyticeffectsofatraditionalmedicinalplantforthemanagementofbehavioraldysfunctionsinanimalmodels
AT hayeeabdul dosedependentantidepressantandanxiolyticeffectsofatraditionalmedicinalplantforthemanagementofbehavioraldysfunctionsinanimalmodels
AT aslammuhammadrahil dosedependentantidepressantandanxiolyticeffectsofatraditionalmedicinalplantforthemanagementofbehavioraldysfunctionsinanimalmodels
AT ahmadkhalil dosedependentantidepressantandanxiolyticeffectsofatraditionalmedicinalplantforthemanagementofbehavioraldysfunctionsinanimalmodels
AT hashmiabdulsattar dosedependentantidepressantandanxiolyticeffectsofatraditionalmedicinalplantforthemanagementofbehavioraldysfunctionsinanimalmodels