Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing

Cells migrate in vivo through complex confining microenvironments, which induce significant nuclear deformation that may lead to nuclear blebbing and nuclear envelope rupture. While actomyosin contractility has been implicated in regulating nuclear envelope integrity, the exact mechanism remains unk...

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Detalles Bibliográficos
Autores principales: Mistriotis, Panagiotis, Wisniewski, Emily O., Bera, Kaustav, Keys, Jeremy, Li, Yizeng, Tuntithavornwat, Soontorn, Law, Robert A., Perez-Gonzalez, Nicolas A., Erdogmus, Eda, Zhang, Yuqi, Zhao, Runchen, Sun, Sean X., Kalab, Petr, Lammerding, Jan, Konstantopoulos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891075/
https://www.ncbi.nlm.nih.gov/pubmed/31690619
http://dx.doi.org/10.1083/jcb.201902057

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