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DNA replication and mitotic entry: A brake model for cell cycle progression
The core function of the cell cycle is to duplicate the genome and divide the duplicated DNA into two daughter cells. These processes need to be carefully coordinated, as cell division before DNA replication is complete leads to genome instability and cell death. Recent observations show that DNA re...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891093/ https://www.ncbi.nlm.nih.gov/pubmed/31712253 http://dx.doi.org/10.1083/jcb.201909032 |
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author | Lemmens, Bennie Lindqvist, Arne |
author_facet | Lemmens, Bennie Lindqvist, Arne |
author_sort | Lemmens, Bennie |
collection | PubMed |
description | The core function of the cell cycle is to duplicate the genome and divide the duplicated DNA into two daughter cells. These processes need to be carefully coordinated, as cell division before DNA replication is complete leads to genome instability and cell death. Recent observations show that DNA replication, far from being only a consequence of cell cycle progression, plays a key role in coordinating cell cycle activities. DNA replication, through checkpoint kinase signaling, restricts the activity of cyclin-dependent kinases (CDKs) that promote cell division. The S/G2 transition is therefore emerging as a crucial regulatory step to determine the timing of mitosis. Here we discuss recent observations that redefine the coupling between DNA replication and cell division and incorporate these insights into an updated cell cycle model for human cells. We propose a cell cycle model based on a single trigger and sequential releases of three molecular brakes that determine the kinetics of CDK activation. |
format | Online Article Text |
id | pubmed-6891093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68910932020-06-02 DNA replication and mitotic entry: A brake model for cell cycle progression Lemmens, Bennie Lindqvist, Arne J Cell Biol Reviews The core function of the cell cycle is to duplicate the genome and divide the duplicated DNA into two daughter cells. These processes need to be carefully coordinated, as cell division before DNA replication is complete leads to genome instability and cell death. Recent observations show that DNA replication, far from being only a consequence of cell cycle progression, plays a key role in coordinating cell cycle activities. DNA replication, through checkpoint kinase signaling, restricts the activity of cyclin-dependent kinases (CDKs) that promote cell division. The S/G2 transition is therefore emerging as a crucial regulatory step to determine the timing of mitosis. Here we discuss recent observations that redefine the coupling between DNA replication and cell division and incorporate these insights into an updated cell cycle model for human cells. We propose a cell cycle model based on a single trigger and sequential releases of three molecular brakes that determine the kinetics of CDK activation. Rockefeller University Press 2019-12-02 2019-11-11 /pmc/articles/PMC6891093/ /pubmed/31712253 http://dx.doi.org/10.1083/jcb.201909032 Text en © 2019 Lemmens and Lindqvist http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Reviews Lemmens, Bennie Lindqvist, Arne DNA replication and mitotic entry: A brake model for cell cycle progression |
title | DNA replication and mitotic entry: A brake model for cell cycle progression |
title_full | DNA replication and mitotic entry: A brake model for cell cycle progression |
title_fullStr | DNA replication and mitotic entry: A brake model for cell cycle progression |
title_full_unstemmed | DNA replication and mitotic entry: A brake model for cell cycle progression |
title_short | DNA replication and mitotic entry: A brake model for cell cycle progression |
title_sort | dna replication and mitotic entry: a brake model for cell cycle progression |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891093/ https://www.ncbi.nlm.nih.gov/pubmed/31712253 http://dx.doi.org/10.1083/jcb.201909032 |
work_keys_str_mv | AT lemmensbennie dnareplicationandmitoticentryabrakemodelforcellcycleprogression AT lindqvistarne dnareplicationandmitoticentryabrakemodelforcellcycleprogression |