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Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy, accounting for up to 17% of deaths in patients with epilepsy. The pathophysiology of SUDEP has remained unclear, largely because it is unpredictable and commonly unwitnessed. This poses a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891182/ https://www.ncbi.nlm.nih.gov/pubmed/31526023 http://dx.doi.org/10.1177/1535759719874787 |
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author | Li, Rui Buchanan, Gordon F. |
author_facet | Li, Rui Buchanan, Gordon F. |
author_sort | Li, Rui |
collection | PubMed |
description | Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy, accounting for up to 17% of deaths in patients with epilepsy. The pathophysiology of SUDEP has remained unclear, largely because it is unpredictable and commonly unwitnessed. This poses a great challenge to studies in patients. Recently, there has been an increase in animal studies to try to better understand the pathophysiology of SUDEP. In this current review, we focus on developments through seizure-induced death models and the preventative strategies they may reveal. |
format | Online Article Text |
id | pubmed-6891182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-68911822020-01-16 Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models Li, Rui Buchanan, Gordon F. Epilepsy Curr Current Review in Basic Science Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy, accounting for up to 17% of deaths in patients with epilepsy. The pathophysiology of SUDEP has remained unclear, largely because it is unpredictable and commonly unwitnessed. This poses a great challenge to studies in patients. Recently, there has been an increase in animal studies to try to better understand the pathophysiology of SUDEP. In this current review, we focus on developments through seizure-induced death models and the preventative strategies they may reveal. SAGE Publications 2019-09-16 /pmc/articles/PMC6891182/ /pubmed/31526023 http://dx.doi.org/10.1177/1535759719874787 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (http://www.creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Current Review in Basic Science Li, Rui Buchanan, Gordon F. Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models |
title | Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models |
title_full | Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models |
title_fullStr | Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models |
title_full_unstemmed | Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models |
title_short | Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models |
title_sort | scurrying to understand sudden expected death in epilepsy: insights from animal models |
topic | Current Review in Basic Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891182/ https://www.ncbi.nlm.nih.gov/pubmed/31526023 http://dx.doi.org/10.1177/1535759719874787 |
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