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Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy, accounting for up to 17% of deaths in patients with epilepsy. The pathophysiology of SUDEP has remained unclear, largely because it is unpredictable and commonly unwitnessed. This poses a...

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Autores principales: Li, Rui, Buchanan, Gordon F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891182/
https://www.ncbi.nlm.nih.gov/pubmed/31526023
http://dx.doi.org/10.1177/1535759719874787
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author Li, Rui
Buchanan, Gordon F.
author_facet Li, Rui
Buchanan, Gordon F.
author_sort Li, Rui
collection PubMed
description Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy, accounting for up to 17% of deaths in patients with epilepsy. The pathophysiology of SUDEP has remained unclear, largely because it is unpredictable and commonly unwitnessed. This poses a great challenge to studies in patients. Recently, there has been an increase in animal studies to try to better understand the pathophysiology of SUDEP. In this current review, we focus on developments through seizure-induced death models and the preventative strategies they may reveal.
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spelling pubmed-68911822020-01-16 Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models Li, Rui Buchanan, Gordon F. Epilepsy Curr Current Review in Basic Science Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy, accounting for up to 17% of deaths in patients with epilepsy. The pathophysiology of SUDEP has remained unclear, largely because it is unpredictable and commonly unwitnessed. This poses a great challenge to studies in patients. Recently, there has been an increase in animal studies to try to better understand the pathophysiology of SUDEP. In this current review, we focus on developments through seizure-induced death models and the preventative strategies they may reveal. SAGE Publications 2019-09-16 /pmc/articles/PMC6891182/ /pubmed/31526023 http://dx.doi.org/10.1177/1535759719874787 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (http://www.creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Current Review in Basic Science
Li, Rui
Buchanan, Gordon F.
Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models
title Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models
title_full Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models
title_fullStr Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models
title_full_unstemmed Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models
title_short Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models
title_sort scurrying to understand sudden expected death in epilepsy: insights from animal models
topic Current Review in Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891182/
https://www.ncbi.nlm.nih.gov/pubmed/31526023
http://dx.doi.org/10.1177/1535759719874787
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