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Possible Mechanisms of Biological Effects Observed in Living Systems during (2)H/(1)H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes
This article presents the original descriptions of some recent physics mechanisms (based on the thermodynamic, kinetic, and quantum tunnel effects) providing stable (2)H/(1)H isotope fractionation, leading to the accumulation of particular isotopic forms in intra- or intercellular space, including t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891295/ https://www.ncbi.nlm.nih.gov/pubmed/31766268 http://dx.doi.org/10.3390/molecules24224101 |
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author | Basov, Alexander Fedulova, Liliya Vasilevskaya, Ekaterina Dzhimak, Stepan |
author_facet | Basov, Alexander Fedulova, Liliya Vasilevskaya, Ekaterina Dzhimak, Stepan |
author_sort | Basov, Alexander |
collection | PubMed |
description | This article presents the original descriptions of some recent physics mechanisms (based on the thermodynamic, kinetic, and quantum tunnel effects) providing stable (2)H/(1)H isotope fractionation, leading to the accumulation of particular isotopic forms in intra- or intercellular space, including the molecular effects of deuterium interaction with (18)O/(17)O/(16)O, (15)N/(14)N, (13)C/(12)C, and other stable biogenic isotopes. These effects were observed mainly at the organelle (mitochondria) and cell levels. A new hypothesis for heavy nonradioactive isotope fractionation in living systems via neutron effect realization is discussed. The comparative analysis of some experimental studies results revealed the following observation: “Isotopic shock” is highly probable and is observed mostly when chemical bonds form between atoms with a summary odd number of neutrons (i.e., bonds with a non-compensated neutron, which correspond to the following equation: Nn − Np = 2k + 1, where k ϵ Z, k is the integer, Z is the set of non-negative integers, Nn is number of neutrons, and Np is number of protons of each individual atom, or in pair of isotopes with a chemical bond). Data on the efficacy and metabolic pathways of the therapy also considered (2)H-modified drinking and diet for some diseases, such as Alzheimer’s disease, Friedreich’s ataxia, mitochondrial disorders, diabetes, cerebral hypoxia, Parkinson’s disease, and brain cancer. |
format | Online Article Text |
id | pubmed-6891295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68912952019-12-12 Possible Mechanisms of Biological Effects Observed in Living Systems during (2)H/(1)H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes Basov, Alexander Fedulova, Liliya Vasilevskaya, Ekaterina Dzhimak, Stepan Molecules Article This article presents the original descriptions of some recent physics mechanisms (based on the thermodynamic, kinetic, and quantum tunnel effects) providing stable (2)H/(1)H isotope fractionation, leading to the accumulation of particular isotopic forms in intra- or intercellular space, including the molecular effects of deuterium interaction with (18)O/(17)O/(16)O, (15)N/(14)N, (13)C/(12)C, and other stable biogenic isotopes. These effects were observed mainly at the organelle (mitochondria) and cell levels. A new hypothesis for heavy nonradioactive isotope fractionation in living systems via neutron effect realization is discussed. The comparative analysis of some experimental studies results revealed the following observation: “Isotopic shock” is highly probable and is observed mostly when chemical bonds form between atoms with a summary odd number of neutrons (i.e., bonds with a non-compensated neutron, which correspond to the following equation: Nn − Np = 2k + 1, where k ϵ Z, k is the integer, Z is the set of non-negative integers, Nn is number of neutrons, and Np is number of protons of each individual atom, or in pair of isotopes with a chemical bond). Data on the efficacy and metabolic pathways of the therapy also considered (2)H-modified drinking and diet for some diseases, such as Alzheimer’s disease, Friedreich’s ataxia, mitochondrial disorders, diabetes, cerebral hypoxia, Parkinson’s disease, and brain cancer. MDPI 2019-11-13 /pmc/articles/PMC6891295/ /pubmed/31766268 http://dx.doi.org/10.3390/molecules24224101 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Basov, Alexander Fedulova, Liliya Vasilevskaya, Ekaterina Dzhimak, Stepan Possible Mechanisms of Biological Effects Observed in Living Systems during (2)H/(1)H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes |
title | Possible Mechanisms of Biological Effects Observed in Living Systems during (2)H/(1)H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes |
title_full | Possible Mechanisms of Biological Effects Observed in Living Systems during (2)H/(1)H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes |
title_fullStr | Possible Mechanisms of Biological Effects Observed in Living Systems during (2)H/(1)H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes |
title_full_unstemmed | Possible Mechanisms of Biological Effects Observed in Living Systems during (2)H/(1)H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes |
title_short | Possible Mechanisms of Biological Effects Observed in Living Systems during (2)H/(1)H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes |
title_sort | possible mechanisms of biological effects observed in living systems during (2)h/(1)h isotope fractionation and deuterium interactions with other biogenic isotopes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891295/ https://www.ncbi.nlm.nih.gov/pubmed/31766268 http://dx.doi.org/10.3390/molecules24224101 |
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